Brimonidine and Oxycodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Brimonidine (brimonidine) and Oxycodone (oxycodone hydrochloride). Common drug interactions include depression among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Brimonidine and Oxycodone. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Brimonidine?

Brimonidine has active ingredients of brimonidine. It is often used in glaucoma. eHealthMe is studying from 6,276 Brimonidine users. Check the latest studies of Brimonidine.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

84 people who take Brimonidine and Oxycodone together, and have interactions are studied.

Brimonidine and Oxycodone drug interactions.

What are the common drug interactions of Brimonidine and Oxycodone, by gender? *:

female:

Depression
Diabetic coma
Emotional disorder
Fall
Leukopenia (less number of white blood cells in blood)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscular weakness (muscle weakness)
Myocarditis (inflammation of heart muscle myocardium)
Nausea (feeling of having an urge to vomit)
Onychoclasis (breaking of the nails)

male:

Chronic kidney disease
Fatigue (feeling of tiredness)
Diarrhoea
Drug ineffective
Gait disturbance
Pain in extremity
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Abdominal pain
Anaemia (lack of blood)

What are the common drug interactions of Brimonidine and Oxycodone, by age (0-1 to 60+)? *:

0-1:

Apnoea (suspension of external breathing)
Depressed level of consciousness
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Hypotonia (low muscle tone)
Lethargy (tiredness)
Respiratory depression (respiration has a rate below 12 breaths)

2-9:

n/a

10-19:

n/a

20-29:

Blood pressure increased
Dizziness

30-39:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

40-49:

Anxiety
Renal failure (kidney dysfunction)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Chronic kidney disease
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Emotional distress
Hyperglycaemia (high blood sugar)
Tooth loss
Bone density decreased
Depression

50-59:

Nightmare (unpleasant dream)
Productive cough
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Red blood cell count decreased
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity)
Arthralgia (joint pain)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

60+:

Chronic kidney disease
Diarrhoea
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Constipation
Decreased interest
Depressed mood
Dry eye (lack of adequate tears)
Emotional disorder
Fall

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 16.67%
Multiple Myeloma (cancer of the plasma cells): 12 people, 14.29%
High Blood Pressure: 10 people, 11.90%
Nausea (feeling of having an urge to vomit): 7 people, 8.33%
Diabetes: 7 people, 8.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 7.14%
Muscle Spasms (muscle contraction): 5 people, 5.95%
Indigestion: 5 people, 5.95%
Hiv Infection: 5 people, 5.95%
Constipation: 5 people, 5.95%

* Approximation only. Some reports may have incomplete information.

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