Brintellix and Atarax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Brintellix (vortioxetine hydrobromide) and Atarax (hydroxyzine hydrochloride). Common drug interactions include electrocardiogram qt prolonged among females and completed suicide among males.

The phase IV clinical study analyzes what interactions people have when they take Brintellix and Atarax. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Brintellix?

Brintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 6,748 Brintellix users. Check the latest studies of Brintellix.

What is Atarax?

Atarax has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 23,553 Atarax users. Check the latest studies of Atarax.



On Jul, 27, 2026

24 people who take Brintellix and Atarax together, and have interactions are studied.

Brintellix and Atarax drug interactions.

What are the common drug interactions of Brintellix and Atarax, by gender? *:

female:

  1. Electrocardiogram qt prolonged
  2. Intentional self-injury
  3. Somnolence (a state of near-sleep, a strong desire for sleep)
  4. Nausea (feeling of having an urge to vomit)
  5. Vomiting
  6. Neck pain
  7. Pyrexia (fever)
  8. Skin reaction
  9. Dizziness
  10. Headache (pain in head)

male:

  1. Completed suicide (act of taking one's own life)
  2. Ageusia (loss of taste functions of the tongue)
  3. Mucosal dryness (dryness of mucous membrane)
  4. Nausea (feeling of having an urge to vomit)
  5. Swelling face
  6. Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)
  7. Vomiting
  8. Pneumonia
  9. Sepsis (a severe blood infection that can lead to organ failure and death)
  10. Aggression

What are the common drug interactions of Brintellix and Atarax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Intentional self-injury
  2. Somnolence (a state of near-sleep, a strong desire for sleep)
  3. Electrocardiogram qt prolonged
  4. Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)
  5. Urinary retention (the inability to completely or partially empty the bladder)
  6. Antipsychotic drug level increased
  7. Dyspnoea (difficult or laboured respiration)
  8. Nausea (feeling of having an urge to vomit)
  9. Ocular hyperaemia (an abnormally large amount of blood in eye)
  10. Rash

30-39:

  1. Neck pain
  2. Pyrexia (fever)
  3. Skin reaction
  4. Abortion spontaneous (naturally occurring miscarriage)
  5. Maternal exposure during pregnancy (use of substance during pregnancy)
  6. Pregnancy

40-49:

  1. Confusional state
  2. Dizziness
  3. Dyspnoea (difficult or laboured respiration)
  4. Electrocardiogram qt prolonged
  5. Headache (pain in head)
  6. Heart rate increased
  7. Hypertension (high blood pressure)
  8. Nausea (feeling of having an urge to vomit)
  9. Vomiting

50-59:

  1. Drug ineffective
  2. Dry mouth
  3. Fall
  4. Fatigue (feeling of tiredness)
  5. Feeling cold
  6. Headache (pain in head)
  7. Hot flush (sudden feelings of heat)
  8. Hyperhidrosis (abnormally increased sweating)
  9. Hypogeusia (reduced ability to taste things (to taste sweet, sour, bitter, or salty substances))
  10. Hyposmia (impairment of the sense of smell)

60+:

  1. Pneumonia
  2. Sepsis (a severe blood infection that can lead to organ failure and death)

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Brintellix and Atarax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Brintellix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Atarax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Brintellix and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Atarax and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on vortioxetine hydrobromide and hydroxyzine hydrochloride (the active ingredients of Brintellix and Atarax, respectively), and Brintellix and Atarax (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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