Methylphenidate and Brintellix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylphenidate (methylphenidate) and Brintellix (vortioxetine hydrobromide). Common drug interactions include syncope among females and suicide attempt among males.

The phase IV clinical study analyzes what interactions people have when they take Methylphenidate and Brintellix. It is created by eHealthMe based on reports of 7 people who take the same drugs from the FDA, and is updated regularly.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,217 Methylphenidate users. Check the latest studies of Methylphenidate.

What is Brintellix?

Brintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 6,748 Brintellix users. Check the latest studies of Brintellix.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Aug, 22, 2026

7 people who take Methylphenidate and Brintellix together, and have interactions are studied.

Methylphenidate and Brintellix drug interactions.

What are the common drug interactions of Methylphenidate and Brintellix, by gender? *:

female:

  1. Syncope (loss of consciousness with an inability to maintain postural tone)
  2. Therapeutic response decreased (less preventive response)

male:

  1. Suicide attempt
  2. Pneumonia

What are the common drug interactions of Methylphenidate and Brintellix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Suicide attempt

20-29:

  1. Pneumonia

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

n/a

* Approximation only. Some reports may have incomplete information.

Do you take Methylphenidate and Brintellix?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Methylphenidate and Brintellix:

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Browse all side effects of Methylphenidate:

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Browse all side effects of Brintellix:

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Browse all interactions between Methylphenidate and drugs from A to Z:

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Browse all interactions between Brintellix and drugs from A to Z:

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How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate and vortioxetine hydrobromide (the active ingredients of Methylphenidate and Brintellix, respectively), and Methylphenidate and Brintellix (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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