Brintellix and Saphris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Brintellix (vortioxetine hydrobromide) and Saphris (asenapine maleate). Common drug interactions include suicidal ideation among females and hyperhidrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Brintellix and Saphris. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Brintellix?

Brintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 6,748 Brintellix users. Check the latest studies of Brintellix.

What is Saphris?

Saphris has active ingredients of asenapine maleate. It is often used in bipolar i disorder. eHealthMe is studying from 8,688 Saphris users. Check the latest studies of Saphris.

On Jul, 20, 2026

51 people who take Brintellix and Saphris together, and have interactions are studied.

Brintellix and Saphris drug interactions.

What are the common drug interactions of Brintellix and Saphris, by gender? *:

female:

Suicidal ideation
Drug ineffective
Abdominal discomfort
Disability
Intervertebral disc protrusion (spinal disc protrusion)
Blood pressure increased
Fall
Infectious mononucleosis (infection usually caused by the epstein-barr virus)
Joint injury
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

male:

Hyperhidrosis (abnormally increased sweating)
Presyncope
Nausea (feeling of having an urge to vomit)
Nightmare (unpleasant dream)
Pain
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sinusitis (inflammation of sinus)
Stress

What are the common drug interactions of Brintellix and Saphris, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hyperhidrosis (abnormally increased sweating)
Presyncope
Vomiting

30-39:

Nightmare (unpleasant dream)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Stress
Therapeutic response unexpected

40-49:

Burning sensation
Diarrhoea
Dizziness
Drug ineffective
Fatigue (feeling of tiredness)
Head discomfort
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)

50-59:

Chronic kidney disease
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal failure (kidney dysfunction)
Nephrogenic anaemia (anaemia due to kidney disease)
Blood potassium decreased
Dry mouth
Fall
Joint injury
Suicidal ideation

60+:

Abdominal discomfort
Abdominal pain
Flat affect (absence of emotional response to a situation)
General physical health deterioration (weak health status)
Headache (pain in head)
Heart rate decreased
Hospitalisation
Insomnia (sleeplessness)
Intervertebral disc protrusion (spinal disc protrusion)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 35 people, 68.63%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 31 people, 60.78%
Stress And Anxiety: 6 people, 11.76%
Sleep Disorder: 5 people, 9.80%
Thyroid Diseases: 3 people, 5.88%
Drowsiness: 3 people, 5.88%
Back Pain: 3 people, 5.88%
Bladder Disorder: 3 people, 5.88%
Blood Pressure Abnormal: 3 people, 5.88%
Constipation: 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Brintellix and Saphris?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously