Brintellix and Zofran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Brintellix (vortioxetine hydrobromide) and Zofran (ondansetron hydrochloride). Common drug interactions include hyperhidrosis among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Brintellix and Zofran. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Brintellix?

Brintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 6,748 Brintellix users. Check the latest studies of Brintellix.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

On Jul, 11, 2026

50 people who take Brintellix and Zofran together, and have interactions are studied.

Brintellix and Zofran drug interactions.

What are the common drug interactions of Brintellix and Zofran, by gender? *:

female:

Hyperhidrosis (abnormally increased sweating)
Memory impairment
Pain
Dysstasia (difficulty in standing)
Malaise (a feeling of general discomfort or uneasiness)
Parathyroid disorder
Anxiety
Decreased appetite
Dizziness
Fall

male:

Headache (pain in head)
Precancerous mucosal lesion
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Allergy to chemicals
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Burning sensation
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)

What are the common drug interactions of Brintellix and Zofran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Erythema (redness of the skin)
Hot flush (sudden feelings of heat)
Pruritus (severe itching of the skin)
Sinusitis (inflammation of sinus)

20-29:

Pain
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Hepatic enzyme increased
Hepatic failure (liver failure)
Laryngitis (inflammation of the larynx)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

30-39:

Dysstasia (difficulty in standing)
Anxiety
Decreased appetite
Dizziness
Food aversion (we reject certain foods for a reason)
Gastric disorder (disease of stomach)
Hunger
Hyperchlorhydria (gastric acid levels are higher in stomach)
Hyperhidrosis (abnormally increased sweating)
Malaise (a feeling of general discomfort or uneasiness)

40-49:

Lethargy (tiredness)
Unresponsive to stimuli
Burning sensation
Coma (state of unconsciousness lasting more than six hours)
Hip arthroplasty
Hypoaesthesia (reduced sense of touch or sensation)
Injection site reaction
Insomnia (sleeplessness)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nightmare (unpleasant dream)

50-59:

Back pain
Humerus fracture (injury to the upper arm bone)
Intervertebral disc disorder (spinal disc disorder)
Laceration (tearing of soft body tissue)
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)
Nasopharyngitis (inflammation of the nasopharynx)
Parathyroid disorder
Patella fracture
Somnambulism (sleep walking)
Tibia fracture (fracture of lower leg bone)

60+:

Drug hypersensitivity
Gastritis (inflammation of stomach)
Laryngitis (inflammation of the larynx)
Plasma cell myeloma (cancer that begins in plasma cells)
Rash generalised (rash on most of body parts)
Sinusitis (inflammation of sinus)
Urinary tract infection

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 36 people, 72.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 18 people, 36.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 8.00%
Stress And Anxiety: 3 people, 6.00%
Insomnia (sleeplessness): 3 people, 6.00%
Drowsiness: 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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