Brivaracetam and Valproate sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Brivaracetam (brivaracetam) and Valproate sodium (valproate sodium). Common drug interactions include nausea among females and seizure among males.

The phase IV clinical study analyzes what interactions people have when they take Brivaracetam and Valproate sodium. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Brivaracetam?

Brivaracetam has active ingredients of brivaracetam. eHealthMe is studying from 3,319 Brivaracetam users. Check the latest studies of Brivaracetam.

What is Valproate sodium?

Valproate sodium has active ingredients of valproate sodium. It is often used in epilepsy. eHealthMe is studying from 24,044 Valproate sodium users. Check the latest studies of Valproate sodium.

On Jul, 12, 2026

44 people who take Brivaracetam and Valproate sodium together, and have interactions are studied.

Brivaracetam and Valproate sodium drug interactions.

What are the common drug interactions of Brivaracetam and Valproate Sodium, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Vomiting
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Anticonvulsant drug level increased
Drug ineffective
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Staphylococcal infection (an infection with staphylococcus bacteria)
Multiple-drug resistance
Tremor (trembling or shaking movements in one or more parts of your body)

male:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Drug ineffective
Confusional state
Multiple-drug resistance
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Tremor (trembling or shaking movements in one or more parts of your body)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Mood altered (changes in mood)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Abnormal behaviour

What are the common drug interactions of Brivaracetam and Valproate Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Drug ineffective
Myoclonic epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs)
Acute hepatic failure
Encephalitis autoimmune (autoimmune origin disturbances of consciousness and pyramidal signs, inflammation of the brain)

10-19:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)

20-29:

Multiple-drug resistance
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Nausea (feeling of having an urge to vomit)
Vomiting
Anxiety disorder
Depression
Hypertension (high blood pressure)
Petit mal epilepsy (absence seizure)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Dizziness

30-39:

Drug ineffective
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Alopecia (absence of hair from areas of the body)
Anticonvulsant drug level increased
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Overdose

40-49:

Drug intolerance (drug sensitivity)
Erectile dysfunction
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Psychiatric symptom
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Weight increased
Drug ineffective
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Anaemia (lack of blood)
Balance disorder

50-59:

Abnormal behaviour
Drug ineffective
Lumbar puncture
Memory impairment
Nausea (feeling of having an urge to vomit)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Therapeutic response unexpected
Weight increased

60+:

Anticonvulsant drug level increased
Limb injury
Weight increased
Death
Overdose
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Staphylococcal infection (an infection with staphylococcus bacteria)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Drug ineffective

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 9 people, 20.45%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 7 people, 15.91%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 11.36%
Partial Seizures (seizures which affect only a part of the brain at onset): 5 people, 11.36%
Petit Mal Epilepsy (absence seizure): 3 people, 6.82%
Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 3 people, 6.82%
Depression: 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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