Buscopan and Actonel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Buscopan (hyoscine butylbromide) and Actonel (risedronate sodium). Common drug interactions include general physical health deterioration among females and enterocolitis among males.

The phase IV clinical study analyzes what interactions people have when they take Buscopan and Actonel. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Buscopan?

Buscopan has active ingredients of hyoscine butylbromide. eHealthMe is studying from 4,828 Buscopan users. Check the latest studies of Buscopan.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

45 people who take Buscopan and Actonel together, and have interactions are studied.

What are the common drug interactions of Buscopan and Actonel, by gender? *:

female:

General physical health deterioration (weak health status)
Haematochezia (passage of stools containing blood)
Head discomfort
Diarrhoea
Fungal infection
Nasopharyngitis (inflammation of the nasopharynx)
Pain in jaw
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Anaemia (lack of blood)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)

male:

Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Febrile neutropenia (fever with reduced white blood cells)
Gastritis (inflammation of stomach)
Neuropathy peripheral (surface nerve damage)
Pneumonia
Pyrexia (fever)

What are the common drug interactions of Buscopan and Actonel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Acute sinusitis
Constipation
Diarrhoea
Dizziness
Enteritis infectious (infection with feline parvovirus (fpv), also known as feline panleucopenia virus)
Epicondylitis (tennis elbow)
Functional gastrointestinal disorder (functional problem in separate organs of gastrointestinal system)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hydronephrosis (water inside the kidney)
Iron deficiency anaemia

30-39:

n/a

40-49:

Nail infection
Nasopharyngitis (inflammation of the nasopharynx)
Oropharyngeal pain
Oxygen saturation decreased
Palpitations (feelings or sensations that your heart is pounding or racing)
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Pyrexia (fever)
Rash
Rubella (an infection of the respiratory system caused by a virus)
Sinusitis (inflammation of sinus)

50-59:

Diarrhoea
Pneumonia
Abdominal pain upper
Anaemia (lack of blood)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Blood cholesterol increased
Blood pressure increased
Blood pressure systolic increased
Constipation
Cough

60+:

Blood pressure diastolic increased
Chest discomfort
Cold sweat
Depressed level of consciousness
Nausea (feeling of having an urge to vomit)
Renal atrophy (wasting of kidney)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Febrile neutropenia (fever with reduced white blood cells)
Gastritis (inflammation of stomach)

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 22 people, 48.89%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 17.78%
Constipation: 7 people, 15.56%
Gastritis (inflammation of stomach): 6 people, 13.33%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 5 people, 11.11%
Pain: 5 people, 11.11%
Insomnia (sleeplessness): 5 people, 11.11%
Dizziness: 5 people, 11.11%
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon): 4 people, 8.89%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 8.89%

* Approximation only. Some reports may have incomplete information.

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