Buspar and Anafranil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Buspar (buspirone hydrochloride) and Anafranil (clomipramine hydrochloride). Common drug interactions include panic attack among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Buspar and Anafranil. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Buspar?

Buspar has active ingredients of buspirone hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 20,463 Buspar users. Check the latest studies of Buspar.

What is Anafranil?

Anafranil has active ingredients of clomipramine hydrochloride. It is often used in obsessive-compulsive disorder. eHealthMe is studying from 6,304 Anafranil users. Check the latest studies of Anafranil.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

58 people who take Buspar and Anafranil together, and have interactions are studied.

What are the common drug interactions of Buspar and Anafranil, by gender? *:

female:

Panic attack
Peripheral swelling
Rash
Suicidal ideation
Tremor (trembling or shaking movements in one or more parts of your body)
Vision blurred
Visual impairment
Vomiting
Aggression
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

male:

Pain
Weight increased
Pulmonary congestion (congestion in the lungs)
Tonsillitis (inflammation of tonsil)
Diabetes mellitus non-insulin-dependent
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hangover
Hypertension (high blood pressure)
Hypokalaemia (low potassium)
Increased appetite

What are the common drug interactions of Buspar and Anafranil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Hypercholesterolaemia (high levels of cholesterol in the blood)

10-19:

Drug ineffective
Joint swelling
Rash
Rash papular (redness with papule)
Rash vesicular (rash with a small bubble)

20-29:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Stillbirth (a birth of dead foetus)

30-39:

Overdose
Pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Priapism (prolonged and painful erection that can last from several hours up to a few days)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Splenomegaly (enlargement of spleen)
Testicular disorder (disease of testes)
White blood cell count increased
Weight increased
Pancreatitis (inflammation of pancreas)

40-49:

Abdominal pain lower
Coeliac disease (simple food intolerance)
Drug ineffective
Food intolerance (inability to have food)
Frequent bowel movements
Gastrointestinal pain
Haematochezia (passage of stools containing blood)
Hepatotoxicity (chemical-driven liver damage)
Muscle spasms (muscle contraction)
Nephrolithiasis (calculi in the kidneys)

50-59:

Back pain
Cardiac failure congestive
Cardiogenic shock (inadequate circulation of blood)
Completed suicide (act of taking one's own life)
Cutaneous lupus erythematosus (own immune system attacks various cells causing a wide variety of signs and symptoms)
Delusion (a false belief or opinion)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dysuria (painful or difficult urination)
Gastric bypass
Glaucoma (increased fluid pressure in the eye with vision loss)

60+:

Drug hypersensitivity
Dyspepsia (indigestion)
Nervousness
Unexpected therapeutic drug effect

What are the existing conditions these people have? *

Pain: 6 people, 10.34%
Back Pain: 5 people, 8.62%
Scoliosis (a medical condition in which a person's spine is curved from side to side): 4 people, 6.90%
Depression: 4 people, 6.90%
Procedural Pain: 3 people, 5.17%
Hallucination, Auditory (perceiving sounds without auditory stimulus): 3 people, 5.17%

* Approximation only. Some reports may have incomplete information.

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