Buspar and Glycopyrrolate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Buspar (buspirone hydrochloride) and Glycopyrrolate (glycopyrrolate). Common drug interactions include hypersomnia among females and blood cholesterol increased among males.

The phase IV clinical study analyzes what interactions people have when they take Buspar and Glycopyrrolate. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Buspar?

Buspar has active ingredients of buspirone hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 20,462 Buspar users. Check the latest studies of Buspar.

What is Glycopyrrolate?

Glycopyrrolate has active ingredients of glycopyrrolate. It is often used in hyperhidrosis. eHealthMe is studying from 5,599 Glycopyrrolate users. Check the latest studies of Glycopyrrolate.



On Jul, 19, 2026

13 people who take Buspar and Glycopyrrolate together, and have interactions are studied.

Buspar and Glycopyrrolate drug interactions.

What are the common drug interactions of Buspar and Glycopyrrolate, by gender? *:

female:

  1. Hypersomnia (excessive daytime sleepiness (eds))
  2. Nausea (feeling of having an urge to vomit)
  3. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  4. Abdominal discomfort
  5. Blood magnesium decreased
  6. Diarrhoea
  7. Dyspnoea (difficult or laboured respiration)
  8. Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
  9. Oral surgery
  10. Weight decreased

male:

  1. Blood cholesterol increased
  2. Dyspepsia (indigestion)
  3. Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
  4. Nephrolithiasis (calculi in the kidneys)
  5. Oesophageal disorder (disease of oesophagus)
  6. Skin ulcer
  7. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
  8. Staphylococcal infection (an infection with staphylococcus bacteria)
  9. Tinea pedis (a contagious skin infection caused by the ringworm fungus)
  10. Varicose vein (veins that have become enlarged and tortuous)

What are the common drug interactions of Buspar and Glycopyrrolate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Hypersomnia (excessive daytime sleepiness (eds))
  2. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  3. Abdominal discomfort
  4. Diarrhoea
  5. Nausea (feeling of having an urge to vomit)
  6. Adverse drug reaction
  7. Hypophagia (reduced food intake)

20-29:

n/a

30-39:

n/a

40-49:

  1. Dyspnoea (difficult or laboured respiration)
  2. Nausea (feeling of having an urge to vomit)
  3. Abdominal distension
  4. Abdominal pain upper
  5. Anal abscess
  6. Back pain
  7. Blood triglycerides increased
  8. Bowel movement irregularity
  9. Colonic polyp (extra part of colon tissue grow in intestine)
  10. Constipation

50-59:

n/a

60+:

  1. Blood cholesterol increased
  2. Dyspepsia (indigestion)
  3. Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
  4. Nephrolithiasis (calculi in the kidneys)
  5. Oesophageal disorder (disease of oesophagus)
  6. Skin ulcer
  7. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
  8. Staphylococcal infection (an infection with staphylococcus bacteria)
  9. Tinea pedis (a contagious skin infection caused by the ringworm fungus)
  10. Varicose vein (veins that have become enlarged and tortuous)

What are the existing conditions these people have? *

  1. Quit Smoking: 3 people, 23.08%
  2. Pain: 3 people, 23.08%
  3. Functional Gastrointestinal Disorder (functional problem in separate organs of gastrointestinal system): 2 people, 15.38%
  4. Drooling (drop saliva uncontrollably from the mouth): 2 people, 15.38%
  5. Hypersensitivity: 2 people, 15.38%
  6. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 15.38%
  7. Facial Spasm (involuntary muscle contractions face): 2 people, 15.38%
  8. Seasonal Allergy (allergic condition due to certain season): 2 people, 15.38%
  9. Constipation: 2 people, 15.38%
  10. Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Buspar and Glycopyrrolate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Buspar:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Glycopyrrolate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Buspar and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Glycopyrrolate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on buspirone hydrochloride and glycopyrrolate (the active ingredients of Buspar and Glycopyrrolate, respectively), and Buspar and Glycopyrrolate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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