Buspar and Narcan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Buspar (buspirone hydrochloride) and Narcan (naloxone hydrochloride). Common drug interactions include nausea among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Buspar and Narcan. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Buspar?

Buspar has active ingredients of buspirone hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 20,463 Buspar users. Check the latest studies of Buspar.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

47 people who take Buspar and Narcan together, and have interactions are studied.

What are the common drug interactions of Buspar and Narcan, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Nerve injury
Overdose
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonia
Rash
Somnolence (a state of near-sleep, a strong desire for sleep)
Drug abuse
General physical health deterioration (weak health status)
Myalgia (muscle pain)

male:

Arthralgia (joint pain)
Hypoaesthesia (reduced sense of touch or sensation)
Chest pain
Chronic obstructive airways disease
Coma (state of unconsciousness lasting more than six hours)
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dyspnoea (difficult or laboured respiration)
Nocturia (the need to get up in the night to urinate)
Wheezing (a high-pitched whistling sound made while you breath)

What are the common drug interactions of Buspar and Narcan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Alanine aminotransferase increased
Anion gap decreased
Arthralgia (joint pain)
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood glucose increased
Blood magnesium increased
Gastric mucosa erythema (reddened mucosa of stomach)
Gastric ulcer haemorrhage (bleeding ulcer of stomach)

20-29:

n/a

30-39:

Arthralgia (joint pain)
Cardiomegaly (increased size of heart than normal)
Delirium (wild excitement)
Drug toxicity
Dyspepsia (indigestion)
Hypoaesthesia (reduced sense of touch or sensation)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Bone pain
Chest pain
Chronic obstructive airways disease

40-49:

Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Nausea (feeling of having an urge to vomit)
Nervousness
Optic ischaemic neuropathy (optic nerve damage due to lack of blood supply)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Aphasia (damage to the parts of the brain that control language)
Chronic kidney disease
Congestive cardiomyopathy (weakening of heart muscle)
Gastrointestinal stromal tumour (a cancer that arises from transformed cells of mesenchymal origin in gastrointestinal tract)

50-59:

Nausea (feeling of having an urge to vomit)
Abdominal abscess (collection of pus in abdomen)
Abdominal discomfort
Ageusia (loss of taste functions of the tongue)
Asthenia (weakness)
Asthma
Balance disorder
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood cholesterol increased
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

60+:

Fall
Pyrexia (fever)
Blood creatinine increased
Brain injury
Cardiac arrest
Clavicle fracture
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Death
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Disseminated intravascular coagulation (systemic activation of blood coagulation)

What are the existing conditions these people have? *

Pain: 10 people, 21.28%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 10.64%
Overdose: 4 people, 8.51%
Muscle Spasms (muscle contraction): 4 people, 8.51%
Nausea (feeling of having an urge to vomit): 3 people, 6.38%
High Blood Cholesterol: 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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