Buspar and Prolixin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Buspar (buspirone hydrochloride) and Prolixin (fluphenazine hydrochloride). Common drug interactions include melaena among females and ataxia among males.

The phase IV clinical study analyzes what interactions people have when they take Buspar and Prolixin. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Buspar?

Buspar has active ingredients of buspirone hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 20,462 Buspar users. Check the latest studies of Buspar.

What is Prolixin?

Prolixin has active ingredients of fluphenazine hydrochloride. It is often used in schizoaffective disorder. eHealthMe is studying from 1,262 Prolixin users. Check the latest studies of Prolixin.

On Jul, 09, 2026

22 people who take Buspar and Prolixin together, and have interactions are studied.

What are the common drug interactions of Buspar and Prolixin, by gender? *:

female:

Melaena (the passage of black, tarry stools)
Neck pain
Neuropathy peripheral (surface nerve damage)
Otitis externa (external ear infection)
Presbyopia (a condition in which the lens of the eye loses its ability to focus, making it difficult to see objects up close)
Pyrexia (fever)
Restless legs syndrome (a powerful urge to move your legs)
Tendonitis (a condition that causes pain and swelling of tendons)
Vaginal infection
Otitis media (inflammation of the middle ear)

male:

Ataxia (loss of full control of bodily movements)
Lethargy (tiredness)
Priapism (prolonged and painful erection that can last from several hours up to a few days)
Speech disorder

What are the common drug interactions of Buspar and Prolixin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abnormal behaviour
Impulse-control disorder
Irritability
Pressure of speech

30-39:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cardiac disorder
Difficulty in walking
Granuloma (a small area of inflammation due to tissue injury)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hyperinsulinism (above normal level of insulin in the blood)
Hypoaesthesia (reduced sense of touch or sensation)
Increased appetite
Infection

40-49:

Type 2 diabetes mellitus
Cardiac disorder
Obesity (having too much body fat)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypertensive cardiomyopathy (heart disease caused by high blood pressure)
Malaise (a feeling of general discomfort or uneasiness)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Overweight
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

50-59:

Otitis externa (external ear infection)
Presbyopia (a condition in which the lens of the eye loses its ability to focus, making it difficult to see objects up close)
Pyrexia (fever)
Restless legs syndrome (a powerful urge to move your legs)
Tendonitis (a condition that causes pain and swelling of tendons)
Type 2 diabetes mellitus
Vaginal infection
Otitis media (inflammation of the middle ear)
Genital pruritus female (itching in vagina)
Otitis media acute (rapid inflammation of the middle ear)

60+:

Drug ineffective
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Depression: 5 people, 22.73%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 18.18%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 18.18%
Sleep Disorder: 3 people, 13.64%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 13.64%
Psychotic Disorder: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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