Buspar and Saphris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Buspar (buspirone hydrochloride) and Saphris (asenapine maleate). Common drug interactions include agitation among females and blood calcium increased among males.

The phase IV clinical study analyzes what interactions people have when they take Buspar and Saphris. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Buspar?

Buspar has active ingredients of buspirone hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 20,462 Buspar users. Check the latest studies of Buspar.

What is Saphris?

Saphris has active ingredients of asenapine maleate. It is often used in bipolar i disorder. eHealthMe is studying from 8,688 Saphris users. Check the latest studies of Saphris.

On Jul, 13, 2026

35 people who take Buspar and Saphris together, and have interactions are studied.

What are the common drug interactions of Buspar and Saphris, by gender? *:

female:

Agitation (state of anxiety or nervous excitement)
Nausea (feeling of having an urge to vomit)
Vomiting
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Polyuria (production of too much dilute urine)
Urinary tract infection
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Insomnia (sleeplessness)
Affective disorder (mental disorder)
Dysgeusia (disorder of the sense of taste)

male:

Blood calcium increased
Defaecation urgency (a sudden compelling urge to defecate)
Diarrhoea
Drug level decreased
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Heart rate increased
Joint swelling
Mania (a state of abnormally elevated or irritable mood)
Oedema peripheral (superficial swelling)

What are the common drug interactions of Buspar and Saphris, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Polyuria (production of too much dilute urine)
Urinary tract infection

20-29:

n/a

30-39:

Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Agitation (state of anxiety or nervous excitement)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Tardive dyskinesia (a disorder that involves involuntary movements)
Vision blurred
Weight increased
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)

40-49:

Affective disorder (mental disorder)
Agitation (state of anxiety or nervous excitement)
Dysgeusia (disorder of the sense of taste)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Intentional self-injury
Joint swelling
Laceration (tearing of soft body tissue)
Loss of consciousness

50-59:

Distractibility (inability to sustain one's attention)
Energy increased
Euphoric mood (excessively happy but may become angry or irritable)
Insomnia (sleeplessness)
Irritability
Mania (a state of abnormally elevated or irritable mood)
Renal failure (kidney dysfunction)
Blood calcium increased
Blood cholesterol increased
Blood glucose increased

60+:

Nausea (feeling of having an urge to vomit)
Vomiting
Agitation (state of anxiety or nervous excitement)
Dizziness
Gait disturbance
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Oral discomfort (pain or irritation in mouth)
Oropharyngeal blistering (blister of oropharynx)
Retching (strong involuntary effort to vomit)
Sudden onset of sleep

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 8 people, 22.86%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 3 people, 8.57%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 8.57%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 8.57%
Schizoaffective Disorder Bipolar Type (mental illness featuring schizophrenia and a mood disorder with mania): 2 people, 5.71%
Affective Disorder (mental disorder): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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