Busulfex and Alkeran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Busulfex (busulfan) and Alkeran (melphalan). Common drug interactions include bacterial infection among females and cytomegalovirus viraemia among males.

The phase IV clinical study analyzes what interactions people have when they take Busulfex and Alkeran. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Busulfex?

Busulfex has active ingredients of busulfan. eHealthMe is studying from 3,408 Busulfex users. Check the latest studies of Busulfex.

What is Alkeran?

Alkeran has active ingredients of melphalan. eHealthMe is studying from 5,429 Alkeran users. Check the latest studies of Alkeran.

On Jul, 17, 2026

66 people who take Busulfex and Alkeran together, and have interactions are studied.

What are the common drug interactions of Busulfex and Alkeran, by gender? *:

female:

Bacterial infection
Blood creatinine increased
Bone sarcoma (bone cancer)
Cytomegalovirus infection
Encephalitis herpes (inflammation of the brain due to herpes infection)
Epistaxis (bleed from the nose)
Epstein-barr virus infection
Febrile neutropenia (fever with reduced white blood cells)
Fungal infection
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

male:

Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Adenovirus infection
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hepatic congestion (liver congestion)
Human herpesvirus 6 infection
Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)
Renal failure acute (rapid kidney dysfunction)
Systemic candida (whole body fungal infection)
Venoocclusive liver disease (small veins in the liver are obstructed)

What are the common drug interactions of Busulfex and Alkeran, by age (0-1 to 60+)? *:

0-1:

Pulmonary oedema (fluid accumulation in the lungs)
Venoocclusive liver disease (small veins in the liver are obstructed)
Ascites (accumulation of fluid in the abdominal cavity)
Bone marrow failure
Haematemesis (vomiting of blood)
Hepatomegaly (abnormal enlargement of the liver)
Melaena (the passage of black, tarry stools)
Pyrexia (fever)
Rash
Peptic ulcer haemorrhage (peptic ulcer bleeding)

2-9:

Cough
Cystitis haemorrhagic (blood in the urine and painful voiding)
Diarrhoea
Diarrhoea haemorrhagic (bloody diarrhoea)
Enterococcal bacteraemia (presence of bacteria lactic acid in the blood)
Enterococcal sepsis
Gastric haemorrhage (bleeding stomach)
Gastric mucosal lesion (lesion of stomach mucous membrane)
Hypersensitivity
Hypertension (high blood pressure)

10-19:

Diarrhoea
Liver disorder (liver diseases)
Nausea (feeling of having an urge to vomit)
Abdominal pain
Acute lymphocytic leukaemia (cancer of the white blood cells)
Arthralgia (joint pain)
Bacterial infection
Blood creatinine increased
Bone sarcoma (bone cancer)
Cough

20-29:

Cystitis haemorrhagic (blood in the urine and painful voiding)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)
Systemic candida (whole body fungal infection)
Bacterial infection
Cardiotoxicity (damage to the heart muscle)
Ejection fraction decreased (systolic heart failure)

30-39:

Hepatitis acute
Septic shock (shock due to blood infection)

40-49:

Cystitis haemorrhagic (blood in the urine and painful voiding)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Infection
Melaena (the passage of black, tarry stools)
Mucous membrane disorder (disease of mucous membrane)

50-59:

Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Human herpesvirus 6 infection
Interstitial lung disease
Sepsis (a severe blood infection that can lead to organ failure and death)
Engraft failure
Pneumonia respiratory syncytial viral (respiratory syncytial virus (rsv) is a very common virus that leads to mild, cold-like symptoms in adults and older healthy children)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Altered state of consciousness (altered state of mind)
Erythema (redness of the skin)

60+:

Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Venoocclusive liver disease (small veins in the liver are obstructed)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Cytomegalovirus enterocolitis (virus infection of intestine and colon)
Death
Encephalitis herpes (inflammation of the brain due to herpes infection)
Interstitial lung disease
Pulmonary haemorrhage (acute bleeding from the lung)

What are the existing conditions these people have? *

Bone Marrow Conditioning Regimen: 24 people, 36.36%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 15 people, 22.73%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 9 people, 13.64%
Infection: 7 people, 10.61%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 7 people, 10.61%
Oedema (fluid collection in tissue): 6 people, 9.09%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 5 people, 7.58%
Allergies: 5 people, 7.58%
Venoocclusive Liver Disease (small veins in the liver are obstructed): 4 people, 6.06%
High Blood Pressure: 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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