Bydureon and Synjardy drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bydureon (exenatide synthetic) and Synjardy (empagliflozin; metformin hydrochloride). Common drug interactions include nasal congestion among females and injection site pain among males.

The phase IV clinical study analyzes what interactions people have when they take Bydureon and Synjardy. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Bydureon?

Bydureon has active ingredients of exenatide synthetic. It is often used in type 2 diabetes. eHealthMe is studying from 24,309 Bydureon users. Check the latest studies of Bydureon.

What is Synjardy?

Synjardy has active ingredients of empagliflozin; metformin hydrochloride. eHealthMe is studying from 2,928 Synjardy users. Check the latest studies of Synjardy.

On Jul, 15, 2026

27 people who take Bydureon and Synjardy together, and have interactions are studied.

Bydureon and Synjardy drug interactions.

What are the common drug interactions of Bydureon and Synjardy, by gender? *:

female:

Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Sinusitis (inflammation of sinus)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Injection site mass
Blood glucose increased
Vomiting
Amputation
Blood cholesterol increased
Hypertension (high blood pressure)
Injection site bruising

male:

Injection site pain
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Alcohol interaction
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Blood glucose increased
Diabetes mellitus inadequate control
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Erythema (redness of the skin)

What are the common drug interactions of Bydureon and Synjardy, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Injection site mass
Injection site pruritus (severe itching at injection site)

40-49:

Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Sepsis (a severe blood infection that can lead to organ failure and death)
Transaminases increased

50-59:

Blood cholesterol increased
Hypertension (high blood pressure)
Injection site bruising
Injection site mass
Abdominal discomfort
Abdominal pain upper
Alcohol interaction
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Arrhythmia (irregular heartbeat)

60+:

Injection site pain
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Amputation
Pain in extremity
Skin ulcer
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Arterial disorder
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Confusional state

What are the existing conditions these people have? *

Diabetes: 7 people, 25.93%
High Blood Pressure: 5 people, 18.52%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 11.11%
Weight Loss: 2 people, 7.41%
High Blood Cholesterol: 2 people, 7.41%
Dyslipidaemia (abnormal amount of lipids): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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