Caffeine and Effexor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Caffeine (caffeine) and Effexor (venlafaxine hydrochloride). Common drug interactions include urinary incontinence among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Caffeine and Effexor. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Caffeine?

Caffeine has active ingredients of caffeine. It is often used in fatigue. eHealthMe is studying from 6,667 Caffeine users. Check the latest studies of Caffeine.

What is Effexor?

Effexor has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 99,496 Effexor users. Check the latest studies of Effexor.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

67 people who take Caffeine and Effexor together, and have interactions are studied.

What are the common drug interactions of Caffeine and Effexor, by gender? *:

female:

Urinary incontinence (inability to control the flow of urine and involuntary urination)
Viral infection
Blood pressure increased
Disability
Memory impairment
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nasopharyngitis (inflammation of the nasopharynx)
Skin disorder (skin disease)
Abdominal distension
Alopecia (absence of hair from areas of the body)

male:

Nausea (feeling of having an urge to vomit)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Drug abuse
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Headache (pain in head)
Hepatic enzyme increased
Insomnia (sleeplessness)
Limb injury
Lipase increased
Neck pain

What are the common drug interactions of Caffeine and Effexor, by age (0-1 to 60+)? *:

0-1:

Maternal exposure during pregnancy (use of substance during pregnancy)
Low birth weight baby
Maternal exposure before pregnancy (use of substance before pregnancy)
Premature baby
Speech disorder developmental

2-9:

n/a

10-19:

n/a

20-29:

Maternal exposure during pregnancy (use of substance during pregnancy)
Multiple-drug resistance
Nausea (feeling of having an urge to vomit)
Premature delivery
Syncope (loss of consciousness with an inability to maintain postural tone)
Maternal exposure before pregnancy (use of substance before pregnancy)
Overdose

30-39:

Haemoglobin decreased
Abdominal discomfort
Acne (skin problems that cause pimples)
Arthralgia (joint pain)
Blood pressure decreased
Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Erythema (redness of the skin)
Eye pain
Gastrointestinal disorder (functional problems of gastrointestinal tract)

40-49:

Chemotherapy
Nausea (feeling of having an urge to vomit)
Surgery
Abdominal pain upper
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Pelvic congestion (a condition in women caused by varicose veins in the lower abdomen)
Stiff person syndrome

50-59:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Depressed mood
Drug abuse
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Feeling of despair
Head injury
Muscle disorder (muscle disease)
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)
Peripheral swelling

60+:

Therapeutic response unexpected
Headache (pain in head)
Decreased appetite
Facial paralysis (loss of function of face muscle)
Femoral neck fracture (neck of femur bone fracture)
Gallbladder disorder
Injury
Insomnia (sleeplessness)
Melaena (the passage of black, tarry stools)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 14.93%
Migraine (headache): 10 people, 14.93%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 10 people, 14.93%
Drowsiness: 8 people, 11.94%
Rickets (softening of bones): 8 people, 11.94%
Headache (pain in head): 8 people, 11.94%
Stress And Anxiety: 7 people, 10.45%
Sleep Disorder: 7 people, 10.45%
Birth Control: 7 people, 10.45%
Post Lumbar Puncture Syndrome: 6 people, 8.96%

* Approximation only. Some reports may have incomplete information.

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