Caffeine and Tegretol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Caffeine (caffeine) and Tegretol (carbamazepine). Common drug interactions include brain injury among females and alcohol interaction among males.

The phase IV clinical study analyzes what interactions people have when they take Caffeine and Tegretol. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Caffeine?

Caffeine has active ingredients of caffeine. It is often used in fatigue. eHealthMe is studying from 6,667 Caffeine users. Check the latest studies of Caffeine.

What is Tegretol?

Tegretol has active ingredients of carbamazepine. It is often used in epilepsy. eHealthMe is studying from 45,969 Tegretol users. Check the latest studies of Tegretol.



On Jul, 03, 2026

84 people who take Caffeine and Tegretol together, and have interactions are studied.

Caffeine and Tegretol drug interactions.

What are the common drug interactions of Caffeine and Tegretol, by gender? *:

female:

  1. Brain injury
  2. Spinal column stenosis (narrowing of spinal column)
  3. Blood pressure increased
  4. Clumsiness (a lack of coordination or elegance)
  5. Craniocerebral injury (injury to cranium and brain)
  6. Depression
  7. Fall
  8. Fear
  9. Head injury
  10. Headache (pain in head)

male:

  1. Alcohol interaction
  2. Overdose
  3. Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
  4. Fall
  5. Gait disturbance
  6. General physical health deterioration (weak health status)
  7. Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)

What are the common drug interactions of Caffeine and Tegretol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Orthostatic intolerance (development of symptoms when standing upright which are relieved when sitting back down again)
  2. Suicide attempt
  3. Pneumonia

20-29:

n/a

30-39:

  1. Alcohol interaction
  2. Overdose
  3. Abortion spontaneous (naturally occurring miscarriage)
  4. Maternal exposure during pregnancy (use of substance during pregnancy)

40-49:

  1. Brain injury
  2. Burning mouth syndrome (pain in the mouth and burning sensation on tongue)
  3. Hypoaesthesia (reduced sense of touch or sensation)
  4. Spinal column stenosis (narrowing of spinal column)
  5. Drug ineffective

50-59:

n/a

60+:

  1. Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
  2. Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
  3. Overdose
  4. Pruritus (severe itching of the skin)
  5. Rash
  6. Renal failure (kidney dysfunction)
  7. Skin exfoliation (removal of the oldest dead skin cells)
  8. Stasis dermatitis (skin inflammation caused by blood pooling in the veins in your legs)
  9. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
  10. Fall

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 31 people, 36.90%
  2. Pain: 20 people, 23.81%
  3. Drug Dependence: 17 people, 20.24%
  4. Burning Mouth Syndrome (pain in the mouth and burning sensation on tongue): 6 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Caffeine and Tegretol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Caffeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Tegretol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Caffeine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tegretol and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on caffeine and carbamazepine (the active ingredients of Caffeine and Tegretol, respectively), and Caffeine and Tegretol (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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