Calan and Cymbalta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Calan (verapamil hydrochloride) and Cymbalta (duloxetine hydrochloride). Common drug interactions include emotional disorder among females and blood urine present among males.

The phase IV clinical study analyzes what interactions people have when they take Calan and Cymbalta. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Calan?

Calan has active ingredients of verapamil hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 3,916 Calan users. Check the latest studies of Calan.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,976 Cymbalta users. Check the latest studies of Cymbalta.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

45 people who take Calan and Cymbalta together, and have interactions are studied.

What are the common drug interactions of Calan and Cymbalta, by gender? *:

female:

Emotional disorder
Enthesopathy (disorder of entheses (bone attachments))
Enuresis (repeated inability to control urination)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Eye irritation
Fall
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Haemoglobin decreased

male:

Blood urine present
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Type 2 diabetes mellitus
Abdominal abscess (collection of pus in abdomen)
Abdominal mass (localized enlargement or swelling in the human abdomen)
Abdominal pain lower
Abnormal dreams

What are the common drug interactions of Calan and Cymbalta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Affective disorder (mental disorder)
Agitation (state of anxiety or nervous excitement)
Arteriosclerosis (thickening and hardening of arteries)
Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Drug ineffective
Folliculitis (infection of hair root)
Hysterectomy
Insomnia (sleeplessness)
Libido decreased (loss of interest in sex)

30-39:

Anaemia (lack of blood)
Oral mucosal exfoliation (removal of mucous membrane of mouth)
Pain in extremity
Swollen tongue (swelling of tongue)
Tongue exfoliation (removal of old layer of tongue)
Back pain
Blood cholesterol increased
Diabetes mellitus inadequate control
Enthesopathy (disorder of entheses (bone attachments))
Hyperlipidaemia (presence of excess lipids in the blood)

40-49:

Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Surgery
Fluid retention (an abnormal accumulation of fluid in the blood)
Headache (pain in head)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Disability
Dyspnoea (difficult or laboured respiration)

50-59:

Dizziness
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Blood pressure decreased
Confusional state
Fatigue (feeling of tiredness)
Abnormal dreams
Alopecia (absence of hair from areas of the body)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Chapped lips (cracking, fissuring, and peeling of the skin f lip)

60+:

Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Death
Hypokalaemia (low potassium)
Insomnia (sleeplessness)
Knee arthroplasty
Lung neoplasm malignant (cancer tumour of lung)
Nephropathy (damage to or disease of a kidney)
Neuropathy peripheral (surface nerve damage)
Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)

What are the existing conditions these people have? *

Migraine (headache): 9 people, 20.00%
Pain: 7 people, 15.56%
Asthma: 6 people, 13.33%
Sleep Disorder: 4 people, 8.89%
Stress And Anxiety: 3 people, 6.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 6.67%
Insomnia (sleeplessness): 3 people, 6.67%
Headache (pain in head): 3 people, 6.67%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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