Cardizem and Butrans drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cardizem (diltiazem hydrochloride) and Butrans (buprenorphine). Common drug interactions include gastrointestinal haemorrhage among females and ankylosing spondylitis among males.

The phase IV clinical study analyzes what interactions people have when they take Cardizem and Butrans. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Cardizem?

Cardizem has active ingredients of diltiazem hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 28,014 Cardizem users. Check the latest studies of Cardizem.

What is Butrans?

Butrans has active ingredients of buprenorphine. It is often used in pain. eHealthMe is studying from 64,148 Butrans users. Check the latest studies of Butrans.

On Jul, 15, 2026

17 people who take Cardizem and Butrans together, and have interactions are studied.

What are the common drug interactions of Cardizem and Butrans, by gender? *:

female:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Headache (pain in head)
Oedema peripheral (superficial swelling)
Pancreatitis acute (sudden inflammation of pancreas)
Pharyngeal erythema (pharyngeal redness)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Amylase increased
Aphthous ulcer (mouth ulcer)
Application site discolouration
Application site erythema (redness of the skin at application site)

male:

Ankylosing spondylitis (type of arthritis affecting the spine)
Back pain
Erythema (redness of the skin)
Flushing (the warm, red condition of human skin)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Petechiae (a small red or purple spot caused by bleeding into the skin)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Vision blurred

What are the common drug interactions of Cardizem and Butrans, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Asthma
Pancreatitis acute (sudden inflammation of pancreas)
Pharyngeal erythema (pharyngeal redness)
Rhinitis allergic (inflammation of the nasal airways due to allergy)

40-49:

Amylase increased
Constipation
Decreased appetite
Dry eye (lack of adequate tears)
Fall
Foot fracture
Fracture
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)

50-59:

n/a

60+:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Petechiae (a small red or purple spot caused by bleeding into the skin)
Pulmonary oedema (fluid accumulation in the lungs)
Vision blurred
Ankylosing spondylitis (type of arthritis affecting the spine)
Back pain
Dry mouth
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 35.29%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 23.53%
Dry Eyes (lack of adequate tears): 4 people, 23.53%
Depression: 3 people, 17.65%
Intervertebral Disc Degeneration (spinal disc degeneration): 3 people, 17.65%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 3 people, 17.65%
Non-Alcoholic Steatohepatitis (liver inflammation caused by a build up of fat in the liver): 3 people, 17.65%
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 3 people, 17.65%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 17.65%
Rickets (softening of bones): 3 people, 17.65%

* Approximation only. Some reports may have incomplete information.

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