Cardizem and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cardizem (diltiazem hydrochloride) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include aortic stenosis among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Cardizem and Excedrin. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Cardizem?

Cardizem has active ingredients of diltiazem hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 28,014 Cardizem users. Check the latest studies of Cardizem.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

On Jul, 19, 2026

54 people who take Cardizem and Excedrin together, and have interactions are studied.

Cardizem and Excedrin drug interactions.

What are the common drug interactions of Cardizem and Excedrin, by gender? *:

female:

Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Areflexia (absence of a reflex)
Arterial disorder
Back pain
Weight decreased
Urinary tract infection
Influenza
Injection site pain
Sinusitis (inflammation of sinus)
Breast mass

male:

Drug ineffective
Chest pain
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Dehydration (dryness resulting from the removal of water)
Depression
Emotional distress
Injury
Malaise (a feeling of general discomfort or uneasiness)
Penile discharge
Penile haemorrhage (penile bleeding)

What are the common drug interactions of Cardizem and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dyspnoea (difficult or laboured respiration)
Urticaria (rash of round, red welts on the skin that itch intensely)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Sleep paralysis (waking up and unable to move or speak)
Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)
Injection site pain
Respiratory disorder (respiratory disease)

40-49:

Breast mass
Injection site pain
Middle ear effusion (fluid in middle ear)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Respiratory tract infection viral
Urinary tract infection
Weight decreased
Anal fissure
Erythema (redness of the skin)
Influenza

50-59:

Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Cytomegalovirus infection
Dizziness
Dyspnoea (difficult or laboured respiration)
Enlarged uvula
Epistaxis (bleed from the nose)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Fungal infection
Hypotension (abnormally low blood pressure)

60+:

Fatigue (feeling of tiredness)
Herpes zoster
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Dyspepsia (indigestion)
Sinusitis (inflammation of sinus)
Upper limb fracture
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cystitis (inflammation of the wall of the bladder)
Dehydration (dryness resulting from the removal of water)
Diarrhoea

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 18 people, 33.33%
Primary Immunodeficiency Syndrome: 7 people, 12.96%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 9.26%
Pain: 4 people, 7.41%
Pulmonary Embolism (blockage of the main artery of the lung): 3 people, 5.56%
Insomnia (sleeplessness): 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Cardizem and Excedrin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously