Cardizem and Hydroxyurea drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cardizem (diltiazem hydrochloride) and Hydroxyurea (hydroxyurea). Common drug interactions include cryptococcosis among females and blood urine present among males.

The phase IV clinical study analyzes what interactions people have when they take Cardizem and Hydroxyurea. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Cardizem?

Cardizem has active ingredients of diltiazem hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 28,014 Cardizem users. Check the latest studies of Cardizem.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,240 Hydroxyurea users. Check the latest studies of Hydroxyurea.

On Aug, 01, 2026

42 people who take Cardizem and Hydroxyurea together, and have interactions are studied.

Cardizem and Hydroxyurea drug interactions.

What are the common drug interactions of Cardizem and Hydroxyurea, by gender? *:

female:

Cryptococcosis (potentially fatal fungal disease)
Decreased interest
Dizziness
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Hip arthroplasty
Lethargy (tiredness)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)

male:

Blood urine present
Diarrhoea
Lymphoedema (localized fluid retention and tissue swelling)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Nephrolithiasis (calculi in the kidneys)
Platelet count decreased
Renal failure (kidney dysfunction)
Chronic kidney disease
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Cardizem and Hydroxyurea, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Joint swelling
Oedema peripheral (superficial swelling)
Palpitations (feelings or sensations that your heart is pounding or racing)

50-59:

Fatigue (feeling of tiredness)
Bladder cyst
Blood urine present
Decreased activity
Depression
Difficulty in walking
Feeling jittery
Haemoglobin decreased
Left ventricular failure (left ventricle fails to contract forcefully)
Mitral valve incompetence (inefficient heart valve)

60+:

Anaemia (lack of blood)
Chronic kidney disease
Lymphoedema (localized fluid retention and tissue swelling)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Nephrolithiasis (calculi in the kidneys)
Platelet count decreased
Weight decreased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Drug ineffective

What are the existing conditions these people have? *

Primary Myelofibrosis (primary disorder of the bone marrow): 7 people, 16.67%
Essential Thrombocythaemia (chronic blood cancer): 6 people, 14.29%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 11.90%
Stress And Anxiety: 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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