Carpine and Cevimeline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Carpine (pilocarpine hydrochloride) and Cevimeline (cevimeline hydrochloride). Common drug interactions include fall among females and drug hypersensitivity among males.

The phase IV clinical study analyzes what interactions people have when they take Carpine and Cevimeline. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Carpine?

Carpine has active ingredients of pilocarpine hydrochloride. eHealthMe is studying from 5,561 Carpine users. Check the latest studies of Carpine.

What is Cevimeline?

Cevimeline has active ingredients of cevimeline hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 1,480 Cevimeline users. Check the latest studies of Cevimeline.

On Jul, 18, 2026

59 people who take Carpine and Cevimeline together, and have interactions are studied.

Carpine and Cevimeline drug interactions.

What are the common drug interactions of Carpine and Cevimeline, by gender? *:

female:

Fall
Arthralgia (joint pain)
Pruritus (severe itching of the skin)
Weight decreased
Allergy to arthropod sting
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Contusion (a type of hematoma of tissue in which capillaries)
Drug hypersensitivity
Dysgeusia (disorder of the sense of taste)
Dysphagia (a condition in which swallowing is difficult or painful)

male:

Drug hypersensitivity
Drug ineffective
Eye irritation
Eye pain
Diarrhoea

What are the common drug interactions of Carpine and Cevimeline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal discomfort
Disability
Food allergy
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)

30-39:

n/a

40-49:

Drug hypersensitivity
Bone tuberculosis
Cardiac failure congestive
Dyspnoea (difficult or laboured respiration)
Fluid overload (too much fluid in the blood)
Nephropathy (damage to or disease of a kidney)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Oxygen consumption increased
Peripheral swelling
Seasonal allergy (allergic condition due to certain season)

50-59:

Infusion related reaction
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Pyrexia (fever)
Dry mouth
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Discomfort
Allergy to arthropod sting
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Contusion (a type of hematoma of tissue in which capillaries)

60+:

Inflammation
Memory impairment
Pruritus (severe itching of the skin)
Skin exfoliation (removal of the oldest dead skin cells)
Sleep disorder
Therapeutic response unexpected
Weight decreased
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Death

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 21 people, 35.59%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 18.64%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 15.25%
Pemphigoid (tense blisters on the skin): 6 people, 10.17%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 10.17%
Iridocyclitis (inflammation of the iris and ciliary body of the eye): 6 people, 10.17%
Dry Mouth: 4 people, 6.78%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 4 people, 6.78%
Drowsiness: 3 people, 5.08%

* Approximation only. Some reports may have incomplete information.

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