Carpine and Relafen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Carpine (pilocarpine hydrochloride) and Relafen (nabumetone). Common drug interactions include periorbital oedema among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Carpine and Relafen. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Carpine?

Carpine has active ingredients of pilocarpine hydrochloride. eHealthMe is studying from 5,561 Carpine users. Check the latest studies of Carpine.

What is Relafen?

Relafen has active ingredients of nabumetone. It is often used in arthritis. eHealthMe is studying from 6,243 Relafen users. Check the latest studies of Relafen.

On Jul, 21, 2026

19 people who take Carpine and Relafen together, and have interactions are studied.

What are the common drug interactions of Carpine and Relafen, by gender? *:

female:

Periorbital oedema (swelling around the eyes)
Pyogenic granuloma (small, raised, red bumps on the skin)
Radiation injury (injuries are caused by radiation)
Restless legs syndrome (a powerful urge to move your legs)
Anxiety
Pelvic fracture
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Delirium (wild excitement)
Delusion (a false belief or opinion)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

male:

Anaemia (lack of blood)
Cellulitis (infection under the skin)
Pyrexia (fever)
Stomatitis (inflammation of mucous membrane of mouth)
Thrombocytopenia (decrease of platelets in blood)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Drug maladministration
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Mouth haemorrhage (bleeding from mouth)
Mucosal inflammation (infection of mucous membrane)

What are the common drug interactions of Carpine and Relafen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthenia (weakness)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dry mouth
Keratoconjunctivitis (inflammation of the cornea and conjunctiva)
Myoclonic jerks (involuntary twitching of a muscle or group of muscles)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Thinking abnormal

40-49:

n/a

50-59:

Headache (pain in head)
Hypoacusis (loss of hearing)
Immunodeficiency
Infection
Liver tenderness (pain and discomfort in liver when touched)
Malaise (a feeling of general discomfort or uneasiness)
Mouth haemorrhage (bleeding from mouth)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Neoplasm malignant (cancer tumour)
Oedema peripheral (superficial swelling)

60+:

Anxiety
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Pain in extremity
Sinusitis (inflammation of sinus)
Adjustment disorder
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Arthralgia (joint pain)
Asthenia (weakness)

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 7 people, 36.84%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 15.79%
Urinary Tract Infection: 2 people, 10.53%
Constipation: 2 people, 10.53%
Essential Hypertension (primary hypertension): 2 people, 10.53%
Insomnia (sleeplessness): 2 people, 10.53%
Itching: 2 people, 10.53%
Oesophageal Disorder (disease of oesophagus): 2 people, 10.53%
Nausea And Vomiting: 2 people, 10.53%
Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

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