Cathflo activase and Keppra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cathflo activase (alteplase) and Keppra (levetiracetam). Common drug interactions include nausea among females and cytokine release syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Cathflo activase and Keppra. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Cathflo activase?

Cathflo activase has active ingredients of alteplase. eHealthMe is studying from 1,469 Cathflo activase users. Check the latest studies of Cathflo activase.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.

On Jul, 18, 2026

42 people who take Cathflo activase and Keppra together, and have interactions are studied.

Cathflo activase and Keppra drug interactions.

What are the common drug interactions of Cathflo Activase and Keppra, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Pyrexia (fever)
Blood pressure fluctuation
Fall
Infusion related reaction
Vomiting
Catheter site infection (infection at the site of insertion)
Chest discomfort
Chills (felling of cold)

male:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Pyrexia (fever)
Headache (pain in head)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Hypoxia (low oxygen in tissues)
Coagulopathy (blood's ability to clot is impaired)
Pneumonia
Atelectasis (partial or complete collapse of the lung)
Diarrhoea
Malignant neoplasm progression (cancer tumour came back)

What are the common drug interactions of Cathflo Activase and Keppra, by age (0-1 to 60+)? *:

0-1:

Abdominal infection
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Ammonia decreased
Anaemia (lack of blood)
Anion gap increased
Aspartate aminotransferase increased
Blast cell count increased
Blood albumin decreased
Blood calcium decreased

2-9:

Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Neutropenia (an abnormally low number of neutrophils)
Platelet count decreased
Pyrexia (fever)
Red blood cell count decreased
White blood cell count decreased
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Escherichia infection (bacterial infection by escherichia coli)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)

10-19:

Pyrexia (fever)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Hypoxia (low oxygen in tissues)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Pericardial effusion (fluid around the heart)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Acute lymphocytic leukaemia (cancer of the white blood cells)
Agitation (state of anxiety or nervous excitement)
Ammonia increased
Apnoea (suspension of external breathing)

20-29:

n/a

30-39:

Blood pressure fluctuation
Fall
Headache (pain in head)
Infusion related reaction
Nausea (feeling of having an urge to vomit)
Vomiting
Catheter site infection (infection at the site of insertion)
Chest discomfort
Chills (felling of cold)
Erythema (redness of the skin)

40-49:

n/a

50-59:

Parkinsonism (degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination)

60+:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Pyrexia (fever)
Chest pain
Electrocardiogram qt prolonged
Fatigue (feeling of tiredness)
Febrile neutropenia (fever with reduced white blood cells)
Gait disturbance
Headache (pain in head)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 9 people, 21.43%
Pain: 8 people, 19.05%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 8 people, 19.05%
Indigestion: 8 people, 19.05%
Constipation: 8 people, 19.05%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 8 people, 19.05%
Fever: 7 people, 16.67%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 6 people, 14.29%
Blood Culture Positive: 5 people, 11.90%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 5 people, 11.90%

* Approximation only. Some reports may have incomplete information.

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