Cefazolin and Phenytoin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cefazolin (cefazolin sodium) and Phenytoin (phenytoin). Common drug interactions include platelet count decreased among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Cefazolin and Phenytoin. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Cefazolin?

Cefazolin has active ingredients of cefazolin sodium. It is often used in infection. eHealthMe is studying from 15,157 Cefazolin users. Check the latest studies of Cefazolin.

What is Phenytoin?

Phenytoin has active ingredients of phenytoin. It is often used in epilepsy. eHealthMe is studying from 15,753 Phenytoin users. Check the latest studies of Phenytoin.

On Jul, 09, 2026

69 people who take Cefazolin and Phenytoin together, and have interactions are studied.

Cefazolin and Phenytoin drug interactions.

What are the common drug interactions of Cefazolin and Phenytoin, by gender? *:

female:

Platelet count decreased
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)
Abdominal discomfort
Abdominal pain
Activities of daily living impaired
Altered state of consciousness (altered state of mind)
Anaemia (lack of blood)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Blood glucose decreased

male:

Pyrexia (fever)
Pneumonia
Renal failure acute (rapid kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Conjunctivitis (pink eye)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Abdominal distension
Abdominal pain
Acidosis (build-up of carbon dioxide in the blood)

What are the common drug interactions of Cefazolin and Phenytoin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematemesis (vomiting of blood)

10-19:

Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Blood creatine phosphokinase increased
Dermatitis medicamentosa (an irritation of the scrotum caused by an allergic reaction to a drug)
Drug eruption (adverse drug reaction of the skin)
Drug hypersensitivity
Encephalopathy (functioning of the brain is affected by some agent or condition)
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Erythema (redness of the skin)
Hypoxic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)

20-29:

Pneumonia
Fall
Pyrexia (fever)
Cardiac arrest
Diabetes insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function)
Haemodynamic instability (disturbances in the blood movement in our body)
Hypotension (abnormally low blood pressure)
Activities of daily living impaired
Altered state of consciousness (altered state of mind)
Anaemia (lack of blood)

30-39:

Abdominal distension
Abdominal pain
Acidosis (build-up of carbon dioxide in the blood)
Anaemia (lack of blood)
Anxiety
Cardiac arrest
Chest pain
Collapse of lung (functional breakdown of lung)
Constipation
Cough

40-49:

C-reactive protein increased
Clavicle fracture
Hypokalaemia (low potassium)
Pneumonia
Pruritus (severe itching of the skin)
Rectal prolapse (falling of rectum from normal place)
Altered state of consciousness (altered state of mind)
Dry skin
International normalised ratio increased
Urine discolouration

50-59:

Encephalopathy (functioning of the brain is affected by some agent or condition)
Eosinophil count increased
Haematoma (collection of blood outside the blood vessels)
Haematuria present (presence of blood in urine due to trauma)
Hepatic steatosis (fatty liver disease)
Hospitalisation
International normalised ratio increased
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Oedema (fluid collection in tissue)

60+:

Pyrexia (fever)
Conjunctivitis (pink eye)
General physical health deterioration (weak health status)
Heart rate decreased
Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Platelet count decreased
Pneumonia
Rash
Renal failure (kidney dysfunction)
Activated partial thromboplastin time prolonged

What are the existing conditions these people have? *

Partial Seizures (seizures which affect only a part of the brain at onset): 8 people, 11.59%
Paraneoplastic Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 8 people, 11.59%
Peritonitis Bacterial (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs by bacterial): 7 people, 10.14%
Sedation: 6 people, 8.70%
High Blood Pressure: 6 people, 8.70%
Pain: 5 people, 7.25%
Cardiac Disorder: 4 people, 5.80%

* Approximation only. Some reports may have incomplete information.

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