Cefixime and Levofloxacin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cefixime (cefixime) and Levofloxacin (levofloxacin; sodium chloride). Common drug interactions include gastrointestinal haemorrhage among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Cefixime and Levofloxacin. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Cefixime?

Cefixime has active ingredients of cefixime. eHealthMe is studying from 3,237 Cefixime users. Check the latest studies of Cefixime.

What is Levofloxacin?

Levofloxacin has active ingredients of levofloxacin; sodium chloride. It is often used in sinusitis. eHealthMe is studying from 16,335 Levofloxacin users. Check the latest studies of Levofloxacin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

17 people who take Cefixime and Levofloxacin together, and have interactions are studied.

Cefixime and Levofloxacin drug interactions.

What are the common drug interactions of Cefixime and Levofloxacin, by gender? *:

female:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Asthenia (weakness)
Nausea (feeling of having an urge to vomit)
Renal failure acute (rapid kidney dysfunction)
Vomiting

male:

Pyrexia (fever)
Cardiac disorder
Gastroenteritis (inflammation of stomach and intestine)
Hypotension (abnormally low blood pressure)
Infusion related reaction
Metastases to bone (cancer spreads to bone)
Prostatitis (inflammation of the prostate gland)
Renal failure acute (rapid kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Serum sickness (hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum)

What are the common drug interactions of Cefixime and Levofloxacin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Appendicitis (inflammation of the appendix)
Febrile neutropenia (fever with reduced white blood cells)
Gastroenteritis (inflammation of stomach and intestine)
Hypotension (abnormally low blood pressure)
Infusion related reaction
Sepsis (a severe blood infection that can lead to organ failure and death)
Serum sickness (hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum)
Abdominal pain
Drug toxicity
Vomiting

20-29:

n/a

30-39:

n/a

40-49:

Colitis pseudomembranous (antibiotic-associated diarrhoea)
Diarrhoea

50-59:

n/a

60+:

Pyrexia (fever)
Cardiac disorder
Renal failure acute (rapid kidney dysfunction)
Tendonitis (a condition that causes pain and swelling of tendons)
Colitis pseudomembranous (antibiotic-associated diarrhoea)
Lung disorder (lung disease)
Methicillin-resistant staphylococcal aureus infection
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Sudden death
Cough

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 3 people, 17.65%
Urinary Tract Infection: 2 people, 11.76%
Tracheitis (an inflammation of the trachea): 2 people, 11.76%
Supraventricular Extrasystoles (premature electrical impulse in the heart, generated above the level of the ventricle): 2 people, 11.76%
Osteoporosis (bones weak and more likely to break): 2 people, 11.76%
Kidney Infection (Pyelonephritis): 2 people, 11.76%
High Blood Pressure: 2 people, 11.76%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 2 people, 11.76%
Dyslipidaemia (abnormal amount of lipids): 2 people, 11.76%
Aplastic Anemia: 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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