Cefixime and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cefixime (cefixime) and Zide (hydrochlorothiazide). Common drug interactions include systemic lupus erythematosus among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Cefixime and Zide. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Cefixime?

Cefixime has active ingredients of cefixime. eHealthMe is studying from 3,237 Cefixime users. Check the latest studies of Cefixime.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

63 people who take Cefixime and Zide together, and have interactions are studied.

What are the common drug interactions of Cefixime and Zide, by gender? *:

female:

Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Thermal burn (burn by heat)
Tooth disorder (tooth disease)
Upper respiratory tract infection
Cellulitis (infection under the skin)
Cough
Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Dyspnoea (difficult or laboured respiration)
Osteomyelitis (infection of bone)
Alanine aminotransferase increased

male:

Fatigue (feeling of tiredness)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Emotional distress
Pain
Discomfort
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Arthralgia (joint pain)
Blood creatinine increased
Cardiac disorder
Cholecystitis (infection of gallbladder)

What are the common drug interactions of Cefixime and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug ineffective
Drug intolerance (drug sensitivity)
Skin lesion
Tooth abscess (pus formation in tooth)
Vaginal infection

30-39:

n/a

40-49:

Ear infection
Furuncle (infection of the hair follicle)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Headache (pain in head)
Injection site pain
Injection site pruritus (severe itching at injection site)
Malaise (a feeling of general discomfort or uneasiness)
Oral pain
Oropharyngeal pain
Panic attack

50-59:

Depression
Aphthous ulcer (mouth ulcer)
Back pain
Fibromyalgia (a long-term condition which causes pain all over the body)
Foot deformity (functional disability of foot)
Migraine (headache)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Photosensitivity reaction
Polyarthritis (arthritis which involves 5 or more joints simultaneously)

60+:

Drug ineffective
Nausea (feeling of having an urge to vomit)
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Procedural pain
Constipation
Erythema (redness of the skin)
Frequent bowel movements
Proctitis (inflammation of the rectum and anus)
Abdominal pain
Anaemia (lack of blood)

What are the existing conditions these people have? *

Pain: 11 people, 17.46%
Immunodeficiency Common Variable: 8 people, 12.70%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 7 people, 11.11%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 7 people, 11.11%
Urinary Tract Infection: 7 people, 11.11%
Asthma: 6 people, 9.52%
Chest Pain: 6 people, 9.52%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 6 people, 9.52%
Insomnia (sleeplessness): 6 people, 9.52%
Constipation: 6 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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