Cefotaxime and Augmentin '125' drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cefotaxime (cefotaxime sodium) and Augmentin '125' (amoxicillin; clavulanate potassium). Common drug interactions include neutropenia among females and thrombocytopenia among males.

The phase IV clinical study analyzes what interactions people have when they take Cefotaxime and Augmentin '125'. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Cefotaxime?

Cefotaxime has active ingredients of cefotaxime sodium. eHealthMe is studying from 7,559 Cefotaxime users. Check the latest studies of Cefotaxime.

What is Augmentin '125'?

Augmentin '125' has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 10,452 Augmentin '125' users. Check the latest studies of Augmentin '125'.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

12 people who take Cefotaxime and Augmentin '125' together, and have interactions are studied.

Cefotaxime and Augmentin '125' drug interactions.

What are the common drug interactions of Cefotaxime and Augmentin '125', by gender? *:

female:

Neutropenia (an abnormally low number of neutrophils)
Alanine aminotransferase increased
Erythema (redness of the skin)
Oedema (fluid collection in tissue)
Rash
Thrombocytopenia (decrease of platelets in blood)
Pyrexia (fever)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

male:

Thrombocytopenia (decrease of platelets in blood)
Arthralgia (joint pain)
Hepatic necrosis (large portions of liver die off due to severe liver disease)
Hepatic steatosis (fatty liver disease)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Hypersensitivity
Hypertransaminasaemia
Leukopenia (less number of white blood cells in blood)
Lymphadenopathy (disease or enlargement of lymph nodes)
Mucosal inflammation (infection of mucous membrane)

What are the common drug interactions of Cefotaxime and Augmentin '125', by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Rash
Thrombocytopenia (decrease of platelets in blood)
Alanine aminotransferase increased
Erythema (redness of the skin)
Neutropenia (an abnormally low number of neutrophils)
Oedema (fluid collection in tissue)
Pyrexia (fever)
Blood catecholamines increased
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)

20-29:

n/a

30-39:

Blood albumin decreased
Cardiac failure
Constipation
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Diarrhoea
Fluid retention (an abnormal accumulation of fluid in the blood)
Fungal infection
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hyperglycaemia (high blood sugar)
Hypertension (high blood pressure)

40-49:

n/a

50-59:

General physical health deterioration (weak health status)
Mucosal inflammation (infection of mucous membrane)
Thrombocytopenia (decrease of platelets in blood)

60+:

Pancreatitis acute (sudden inflammation of pancreas)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

What are the existing conditions these people have? *

Sinusitis (inflammation of sinus): 4 people, 33.33%
Empyema (collection of pus in a cavity in the body): 3 people, 25.00%
Sedation: 1 person, 8.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 8.33%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 8.33%
Oedema (fluid collection in tissue): 1 person, 8.33%
Non-Hodgkin's Lymphoma Recurrent (reoccurrence malignant (cancer) cells form in the lymph system): 1 person, 8.33%
Hiv Infection: 1 person, 8.33%
High Blood Cholesterol: 1 person, 8.33%
Fever: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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