Cefotaxime and Trimethoprim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cefotaxime (cefotaxime sodium) and Trimethoprim (trimethoprim). Common drug interactions include blood potassium increased among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Cefotaxime and Trimethoprim. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Cefotaxime?

Cefotaxime has active ingredients of cefotaxime sodium. eHealthMe is studying from 7,559 Cefotaxime users. Check the latest studies of Cefotaxime.

What is Trimethoprim?

Trimethoprim has active ingredients of trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 8,213 Trimethoprim users. Check the latest studies of Trimethoprim.

On Jul, 08, 2026

23 people who take Cefotaxime and Trimethoprim together, and have interactions are studied.

Cefotaxime and Trimethoprim drug interactions.

What are the common drug interactions of Cefotaxime and Trimethoprim, by gender? *:

female:

Blood potassium increased
Gastroenteritis (inflammation of stomach and intestine)
Renal impairment (severely reduced kidney function)
Renal disorder (kidney disease)

male:

Anxiety
Tremor (trembling or shaking movements in one or more parts of your body)
Blood potassium increased
Blood urea increased
Abdominal pain
Arrhythmia (irregular heartbeat)
Cardiac fibrillation (uncontrolled muscle contraction of heart)
Alanine aminotransferase increased
Altered state of consciousness (altered state of mind)
Aspartate aminotransferase increased

What are the common drug interactions of Cefotaxime and Trimethoprim, by age (0-1 to 60+)? *:

0-1:

Blood potassium increased
Renal disorder (kidney disease)

2-9:

Device dislocation
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Weight gain poor

10-19:

Abdominal distension
Abdominal pain
Altered state of consciousness (altered state of mind)
Bacteraemia (presence of bacteria in the blood)
Bone marrow failure
C-reactive protein increased
Confusional state
Csf culture positive
Drug resistance (reduction in effectiveness of a drug)
Headache (pain in head)

20-29:

n/a

30-39:

n/a

40-49:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Liver transplant rejection (failure of liver transplant)

50-59:

Arrhythmia (irregular heartbeat)
Cardiac fibrillation (uncontrolled muscle contraction of heart)
Lower respiratory tract infection
Anxiety
Tremor (trembling or shaking movements in one or more parts of your body)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Drug toxicity
Cardiac arrest
Ventricular fibrillation (abnormally irregular heart rhythm)
Blood potassium increased

60+:

Gastroenteritis (inflammation of stomach and intestine)
Renal impairment (severely reduced kidney function)

What are the existing conditions these people have? *

Fever: 6 people, 26.09%
Respiratory Disorder (respiratory disease): 4 people, 17.39%
Pain: 4 people, 17.39%
Nervous System Disorder (a general class of medical conditions affecting the nervous system): 4 people, 17.39%
Abdominal Pain: 3 people, 13.04%
Lower Respiratory Tract Infection: 3 people, 13.04%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 2 people, 8.70%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 2 people, 8.70%
Constipation: 2 people, 8.70%
Dyspnea (difficult or laboured breathing): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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