Cefotaxime and Tylenol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cefotaxime (cefotaxime sodium) and Tylenol (acetaminophen). Common drug interactions include electrocardiogram qt prolonged among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Cefotaxime and Tylenol. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Cefotaxime?

Cefotaxime has active ingredients of cefotaxime sodium. eHealthMe is studying from 7,559 Cefotaxime users. Check the latest studies of Cefotaxime.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,310 Tylenol users. Check the latest studies of Tylenol.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

58 people who take Cefotaxime and Tylenol together, and have interactions are studied.

Cefotaxime and Tylenol drug interactions.

What are the common drug interactions of Cefotaxime and Tylenol, by gender? *:

female:

Electrocardiogram qt prolonged
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Otitis media (inflammation of the middle ear)
Respiratory failure (inadequate gas exchange by the respiratory system)
Surgery
Anaemia (lack of blood)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Back pain
Cough
Crying

male:

Pyrexia (fever)
Diarrhoea
Constipation
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspnoea (difficult or laboured respiration)
Endocarditis (inflammation in heart muscle)
Hypotension (abnormally low blood pressure)
Laryngomalacia (a congenital softening of the tissues of the larynx)
Pericardial effusion (fluid around the heart)
Pneumonia

What are the common drug interactions of Cefotaxime and Tylenol, by age (0-1 to 60+)? *:

0-1:

Electrolyte imbalance
Cerebral ventricle dilatation (enlargement of ventricle of brain)
Clonic convulsion (long lasting seizure)
Hydrocephalus (water on the brain)
Hyperkalaemia (damage to or disease of the kidney)
Retinopathy of prematurity (retina damage in premature)
Anaemia (lack of blood)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Decreased activity
Dehydration (dryness resulting from the removal of water)

2-9:

Pyrexia (fever)
Crying
Pruritus (severe itching of the skin)
Rigors (an episode of shaking or exaggerated shivering)
Vomiting
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Pain in limb

10-19:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Endocarditis (inflammation in heart muscle)
Fatigue (feeling of tiredness)
Laryngomalacia (a congenital softening of the tissues of the larynx)
Pericardial effusion (fluid around the heart)
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Respiratory distress (difficulty in breathing)
Respiratory tract oedema (swelling of respiratory tract due to excess fluid collection in tissue)
Streptococcal bacteraemia (a bacterial infection of blood)

20-29:

n/a

30-39:

Cholecystitis (infection of gallbladder)

40-49:

Electrocardiogram qt prolonged
Electrocardiogram qt corrected interval prolonged
International normalised ratio increased
Oxygen saturation decreased
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)

50-59:

Anxiety
Asthma
Chest pain
Constipation
Cough
Diarrhoea
Disease progression
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Duodenal ulcer
Emotional distress

60+:

Blood bilirubin increased
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Sepsis (a severe blood infection that can lead to organ failure and death)
Surgery
Abasia (inability to walk)
Apnoea (suspension of external breathing)
Arthralgia (joint pain)
Asthma

What are the existing conditions these people have? *

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 4 people, 6.90%
Hypersensitivity: 3 people, 5.17%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 3 people, 5.17%
Fever: 3 people, 5.17%
Cough: 3 people, 5.17%
Cardiac Enzymes Increased: 3 people, 5.17%

* Approximation only. Some reports may have incomplete information.

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