Centrum and Butrans drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) and Butrans (buprenorphine). Common drug interactions include rash among females and somnolence among males.

The phase IV clinical study analyzes what interactions people have when they take Centrum and Butrans. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

What is Butrans?

Butrans has active ingredients of buprenorphine. It is often used in pain. eHealthMe is studying from 64,148 Butrans users. Check the latest studies of Butrans.

On Jul, 09, 2026

21 people who take Centrum and Butrans together, and have interactions are studied.

What are the common drug interactions of Centrum and Butrans, by gender? *:

female:

Rash
Application site discharge
Application site discolouration
Application site pain
Application site pruritus (application site severe itching of the skin)
Application site vesicles (small bubble within a cell at application site)
Haemorrhage (bleeding)
Drug dependence
Drug ineffective
Bacterial infection

male:

Somnolence (a state of near-sleep, a strong desire for sleep)
Accelerated hypertension (significant hypertension)
Hepatic enzyme increased
Hypersensitivity
Infection
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Tooth extraction
Tooth infection
Toothache (tooth pain)
Urinary retention (the inability to completely or partially empty the bladder)

What are the common drug interactions of Centrum and Butrans, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Bacterial infection
Gamma-glutamyltransferase increased

50-59:

Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Carotid artery occlusion (artery blockage)
Chronic kidney disease
Deafness unilateral
Drug ineffective
Eye swelling
Feeding disorder (when children refuse to eat certain food groups)
Inflammation
Insomnia (sleeplessness)
Intervertebral disc operation

60+:

Application site discharge
Application site discolouration
Dementia (madness)
Dental caries
Drug dependence
Hepatic enzyme increased
Hypersensitivity
Infection
Somnolence (a state of near-sleep, a strong desire for sleep)
Tooth extraction

What are the existing conditions these people have? *

Back Pain: 4 people, 19.05%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 19.05%
High Blood Pressure: 4 people, 19.05%
Diabetes: 3 people, 14.29%
Neck Pain: 3 people, 14.29%
Nausea (feeling of having an urge to vomit): 3 people, 14.29%
High Blood Cholesterol: 3 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 14.29%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 14.29%
Depression: 3 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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