Centrum and Opdivo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) and Opdivo (nivolumab). Common drug interactions include malignant neoplasm progression among females and malignant neoplasm progression among males.

The phase IV clinical study analyzes what interactions people have when they take Centrum and Opdivo. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

What is Opdivo?

Opdivo has active ingredients of nivolumab. eHealthMe is studying from 56,331 Opdivo users. Check the latest studies of Opdivo.

On Jul, 17, 2026

31 people who take Centrum and Opdivo together, and have interactions are studied.

What are the common drug interactions of Centrum and Opdivo, by gender? *:

female:

Malignant neoplasm progression (cancer tumour came back)
Constipation
Diarrhoea
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood pressure increased
Eructation (release of gas from the digestive tract)
Hallucination, visual (seeing things that aren't there)
Hyperkeratosis (thickening of the outer layer of the skin)
Malignant pleural effusion (a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue lining of lung)

male:

Malignant neoplasm progression (cancer tumour came back)
Diarrhoea
Asthenia (weakness)
Back pain
Blood glucose decreased
Blood glucose increased
Blood pressure decreased
Blood pressure increased
Colitis (inflammation of colon)
Confusional state

What are the common drug interactions of Centrum and Opdivo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Diarrhoea
Hyperkeratosis (thickening of the outer layer of the skin)
Dehydration (dryness resulting from the removal of water)
Eructation (release of gas from the digestive tract)
Metastases to bone (cancer spreads to bone)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Skin exfoliation (removal of the oldest dead skin cells)
Amyloidosis (a tumour within which amyloid is produced)
Arthralgia (joint pain)
Asthenia (weakness)

What are the existing conditions these people have? *

Renal Cell Carcinoma (a kidney cancer): 11 people, 35.48%
Malignant Melanoma (skin cancer rises from melancytes): 4 people, 12.90%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 3 people, 9.68%
Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage)): 2 people, 6.45%
Prostate Cancer: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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