Centrum and Prograf drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) and Prograf (tacrolimus). Common drug interactions include abdominal pain among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Centrum and Prograf. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

What is Prograf?

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.

On Jul, 14, 2026

98 people who take Centrum and Prograf together, and have interactions are studied.

What are the common drug interactions of Centrum and Prograf, by gender? *:

female:

Abdominal pain
Back pain
Bacteraemia (presence of bacteria in the blood)
Blood testosterone decreased
Cellulitis (infection under the skin)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Colitis (inflammation of colon)
Conjunctival disorder (conjunctival disease)
Conjunctival oedema (conjunctival swelling)
Constipation

male:

Headache (pain in head)
Ascites (accumulation of fluid in the abdominal cavity)
Pleural effusion (water on the lungs)
Rash
Sepsis (a severe blood infection that can lead to organ failure and death)
Anaemia (lack of blood)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest discomfort
Concomitant disease progression (progress in accompanying disease)

What are the common drug interactions of Centrum and Prograf, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anaemia (lack of blood)
Anxiety
Bipolar disorder (mood disorder)
Colitis ulcerative (inflammation of colon with ulcer)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Depression
Epistaxis (bleed from the nose)
Inflammatory bowel disease
Insomnia (sleeplessness)
Irritable bowel syndrome

30-39:

Angioedema (rapid swelling of the dermis)
Dyspnoea (difficult or laboured respiration)

40-49:

Cerebellar haemorrhage (bleeding in cerebeller)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hydrocephalus (water on the brain)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Blood pressure increased
Heart rate increased
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

50-59:

Cellulitis (infection under the skin)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Colitis (inflammation of colon)
Conjunctival disorder (conjunctival disease)
Conjunctival oedema (conjunctival swelling)
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Cushingoid (obesity and weakening of the muscles)
Cytomegalovirus infection
Cytomegalovirus viraemia (cytomegalo virus in blood stream)

60+:

Death
Dyspnoea (difficult or laboured respiration)
Renal failure acute (rapid kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)
Herpes zoster
Blood glucose increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest discomfort
Concomitant disease progression (progress in accompanying disease)

What are the existing conditions these people have? *

Pain: 17 people, 17.35%
High Blood Cholesterol: 15 people, 15.31%
Diabetes: 14 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 13.27%
Diarrhea: 11 people, 11.22%
Sleep Disorder: 10 people, 10.20%
High Blood Pressure: 8 people, 8.16%
Blood Phosphorus Decreased: 8 people, 8.16%
Arterial Disorder: 8 people, 8.16%
Angiopathy (generic term for a disease of the blood vessels): 8 people, 8.16%

* Approximation only. Some reports may have incomplete information.

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