Centrum and Rapamune drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) and Rapamune (sirolimus). Common drug interactions include malaise among females and weight decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Centrum and Rapamune. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

What is Rapamune?

Rapamune has active ingredients of sirolimus. It is often used in kidney transplant. eHealthMe is studying from 13,848 Rapamune users. Check the latest studies of Rapamune.

On Jun, 16, 2026

44 people who take Centrum and Rapamune together, and have interactions are studied.

What are the common drug interactions of Centrum and Rapamune, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Cardiac disorder
Anaemia (lack of blood)
Asthenia (weakness)
Chest pain
Rash pruritic (redness with itching)
Urinary tract infection
Vitamin d decreased
Aortic dilatation
Drug exposure during pregnancy

male:

Weight decreased
Hot flush (sudden feelings of heat)
Fluid retention (an abnormal accumulation of fluid in the blood)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Oedema peripheral (superficial swelling)
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Depression
Irritability
Libido decreased (loss of interest in sex)
Listless (lack of interest, energy, or spirit)

What are the common drug interactions of Centrum and Rapamune, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hospitalisation
Body temperature increased
Pneumonia pseudomonal (pseudomonas pneumonia is an infection caused by the microbe known as pseudomonas aeruginosa)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Dyspnoea (difficult or laboured respiration)
Cough
Platelet count decreased
Pneumonia
Colorectal cancer stage ii (cancer has grown into the outermost layers of the colon or rectum to near organ)
Dacryostenosis acquired (obstruction of the nasolacrimal duct-acquired)
Fluid retention (an abnormal accumulation of fluid in the blood)
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Weight decreased
Infection

60+:

Hot flush (sudden feelings of heat)
Upper respiratory tract infection
Vitamin d decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
Herpes zoster
Pancreatitis (inflammation of pancreas)
Sinusitis (inflammation of sinus)
Fall
Cystitis (inflammation of the wall of the bladder)

What are the existing conditions these people have? *

High Blood Pressure: 8 people, 18.18%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 13.64%
High Blood Cholesterol: 6 people, 13.64%
Multiple Myeloma (cancer of the plasma cells): 5 people, 11.36%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 11.36%
Constipation: 4 people, 9.09%
Cough: 4 people, 9.09%
Diabetes: 4 people, 9.09%
Indigestion: 4 people, 9.09%
Anaemia (lack of blood): 4 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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