Centrum and Tykerb drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) and Tykerb (lapatinib ditosylate). Common drug interactions include diarrhoea among females.

The phase IV clinical study analyzes what interactions people have when they take Centrum and Tykerb. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

What is Tykerb?

Tykerb has active ingredients of lapatinib ditosylate. It is often used in breast cancer. eHealthMe is studying from 12,231 Tykerb users. Check the latest studies of Tykerb.

On Jul, 15, 2026

26 people who take Centrum and Tykerb together, and have interactions are studied.

What are the common drug interactions of Centrum and Tykerb, by gender? *:

female:

Diarrhoea
Gingival pain (gum pain)
Dry skin
Dysphagia (a condition in which swallowing is difficult or painful)
Glossoptosis
Haemorrhage (bleeding)
Metastasis (spreadable cancer to other organ from origin)
Muscle contractions involuntary (uncontrolled muscle contraction)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Therapeutic response decreased (less preventive response)

male:

n/a

What are the common drug interactions of Centrum and Tykerb, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Diarrhoea
Gingival pain (gum pain)
Hepatic enzyme increased
Glossoptosis
Muscle contractions involuntary (uncontrolled muscle contraction)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Abdominal pain upper
Death
Eructation (release of gas from the digestive tract)
Flatulence (flatus expelled through the anus)

60+:

Diarrhoea
Abdominal pain upper
Back pain
Blood ph decreased
Cardiac disorder
Death
Dehydration (dryness resulting from the removal of water)
Depressed level of consciousness
Dizziness
Drug ineffective

What are the existing conditions these people have? *

Gastric Ulcer (stomach ulcer): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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