Centrum and Wellbutrin xl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) and Wellbutrin xl (bupropion hydrochloride). Common drug interactions include dizziness among females and pollakiuria among males.

The phase IV clinical study analyzes what interactions people have when they take Centrum and Wellbutrin xl. It is created by eHealthMe based on reports of 97 people who take the same drugs from the FDA, and is updated regularly.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

What is Wellbutrin xl?

Wellbutrin xl has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 22,999 Wellbutrin xl users. Check the latest studies of Wellbutrin xl.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

97 people who take Centrum and Wellbutrin xl together, and have interactions are studied.

Centrum and Wellbutrin xl drug interactions.

What are the common drug interactions of Centrum and Wellbutrin Xl, by gender? *:

female:

Dizziness
Drug ineffective
Dry mouth
Dyspnoea (difficult or laboured respiration)
Gallbladder disorder
Myalgia (muscle pain)
Neuralgia (pain in one or more nerves)
Pain in extremity
Pulmonary embolism (blockage of the main artery of the lung)
Sinusitis (inflammation of sinus)

male:

Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Constipation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Eructation (release of gas from the digestive tract)
Faecal incontinence (a lack of control over passing stool)
Gait disturbance
Impaired self-care
Inappropriate affect

What are the common drug interactions of Centrum and Wellbutrin Xl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anal abscess
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Sinusitis (inflammation of sinus)
Tooth abscess (pus formation in tooth)
Tooth extraction
Crying
Dizziness
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)
Screaming (a long loud piercing cry)

30-39:

Cholecystitis acute (rapid infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gallbladder disorder
Pain
Decreased appetite
Eye movement disorder
Food craving
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Pruritus generalised (generalized itching)

40-49:

Suicidal ideation
Abdominal discomfort
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Bipolar disorder (mood disorder)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diarrhoea
Flushing (the warm, red condition of human skin)
Food craving
Headache (pain in head)
Myodesopsia (appearance of spots or strings in an individual's field of vision)

50-59:

Dysarthria (speech disorder)
Dysuria (painful or difficult urination)
Fall
Flushing (the warm, red condition of human skin)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Myalgia (muscle pain)
Neuralgia (pain in one or more nerves)
Vitamin b12 increased
Weight increased
Dysphagia (a condition in which swallowing is difficult or painful)

60+:

Pruritus (severe itching of the skin)
Constipation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Eructation (release of gas from the digestive tract)
Faecal incontinence (a lack of control over passing stool)
Impaired self-care
Inappropriate affect
Insomnia (sleeplessness)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 20 people, 20.62%
Pain: 16 people, 16.49%
Stress And Anxiety: 13 people, 13.40%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 10.31%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 9.28%
Sleep Disorder: 7 people, 7.22%
Nausea (feeling of having an urge to vomit): 7 people, 7.22%
Muscle Spasms (muscle contraction): 7 people, 7.22%
High Blood Pressure: 7 people, 7.22%
High Blood Cholesterol: 7 people, 7.22%

* Approximation only. Some reports may have incomplete information.

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