Centrum and Yaz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) and Yaz (drospirenone; ethinyl estradiol). Common drug interactions include cholelithiasis among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Centrum and Yaz. It is created by eHealthMe based on reports of 88 people who take the same drugs from the FDA, and is updated regularly.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

What is Yaz?

Yaz has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 41,514 Yaz users. Check the latest studies of Yaz.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

88 people who take Centrum and Yaz together, and have interactions are studied.

What are the common drug interactions of Centrum and Yaz, by gender? *:

female:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Gallbladder disorder
Cholecystitis chronic (long lasting infection of gallbladder)
Anxiety
Vomiting
Pain in extremity
Abdominal pain upper
Abdominal pain

male:

Abdominal pain
Cholecystitis chronic (long lasting infection of gallbladder)
Gallbladder disorder
Gallbladder non-functioning
Irritable bowel syndrome
Prostate cancer

What are the common drug interactions of Centrum and Yaz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Jugular vein thrombosis (clot in jugular vein)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Deformity (disfigurement)
Injury
Thrombosis (formation of a blood clot inside a blood vessel)
Arterial thrombosis (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system)
Muscle atrophy (a decrease in the mass of the muscle)

20-29:

Pain
Dyspnoea (difficult or laboured respiration)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Injury
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Pain in extremity
Pulmonary embolism (blockage of the main artery of the lung)
Cholecystitis chronic (long lasting infection of gallbladder)
Oedema peripheral (superficial swelling)
Abdominal pain

30-39:

Anxiety
Pleuritic pain
Pulmonary infarction (death of a small area of lung)
Abdominal distension
Constipation
General physical health deterioration (weak health status)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Disturbance in attention
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Gallbladder cholesterolosis (accumulation and deposition of cholesterol inside of the)

40-49:

Pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)
Anxiety
Asthenia (weakness)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Oedema peripheral (superficial swelling)
Depression
Fall
Heart injury

50-59:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Pain in extremity
Abasia (inability to walk)
Anxiety
Aphagia (inability or refusal to swallow)
Brain injury
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

60+:

Cholecystitis chronic (long lasting infection of gallbladder)
Nausea (feeling of having an urge to vomit)
Pain
Prostate cancer
Weight decreased
Abdominal pain
Abdominal pain upper
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea
Gallbladder disorder

What are the existing conditions these people have? *

Premenstrual Syndrome: 25 people, 28.41%
Acne (skin problems that cause pimples): 16 people, 18.18%
Pain: 11 people, 12.50%
Depression: 8 people, 9.09%
Headache (pain in head): 7 people, 7.95%
Thyroid Diseases: 6 people, 6.82%
Stress And Anxiety: 6 people, 6.82%
High Blood Cholesterol: 6 people, 6.82%
Sleep Disorder: 5 people, 5.68%
Polycystic Ovary Disease (cysts in the ovaries that occurs when the follicle stops developing): 5 people, 5.68%

* Approximation only. Some reports may have incomplete information.

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