Cephalexin and Nucynta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cephalexin (cephalexin) and Nucynta (tapentadol hydrochloride). Common drug interactions include psychogenic pain disorder among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Cephalexin and Nucynta. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Cephalexin?

Cephalexin has active ingredients of cephalexin. It is often used in infection. eHealthMe is studying from 30,580 Cephalexin users. Check the latest studies of Cephalexin.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

On Jul, 10, 2026

77 people who take Cephalexin and Nucynta together, and have interactions are studied.

Cephalexin and Nucynta drug interactions.

What are the common drug interactions of Cephalexin and Nucynta, by gender? *:

female:

Psychogenic pain disorder
Quality of life decreased
Renal impairment (severely reduced kidney function)
Renal transplant
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Social avoidant behaviour (avoiding social connection a personality disorder)
Substance-induced psychotic disorder
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Anxiety disorder

male:

Chronic kidney disease
Nephrolithiasis (calculi in the kidneys)
Blood calcium decreased
Bone pain
Diarrhoea
Haemochromatosis (body to absorb more iron than usual from food)
Hot flush (sudden feelings of heat)
Malignant neoplasm progression (cancer tumour came back)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Cephalexin and Nucynta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pulmonary embolism (blockage of the main artery of the lung)
Injury

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

30-39:

Alopecia (absence of hair from areas of the body)
Renal failure (kidney dysfunction)
Abdominal pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Decreased activity
Dizziness
Emotional distress
Fatigue (feeling of tiredness)

40-49:

Renal failure (kidney dysfunction)
Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Decreased activity
Emotional distress
Fatigue (feeling of tiredness)
Quality of life decreased
Renal transplant
Dizziness

50-59:

Abdominal pain
Anxiety
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Cardiac murmur (an heart sound in valve abnormality)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cataract (clouding of the lens inside the eye)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertension (high blood pressure)
Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)

60+:

Chronic kidney disease
Nephrolithiasis (calculi in the kidneys)
Death
Depression
Diarrhoea
Fatigue (feeling of tiredness)
Headache (pain in head)
Hereditary angioedema (recurrent episodes of severe swelling)
Hot flush (sudden feelings of heat)
Hyperkalaemia (damage to or disease of the kidney)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 25 people, 32.47%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 16 people, 20.78%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 14 people, 18.18%
High Blood Cholesterol: 12 people, 15.58%
Asthma: 11 people, 14.29%
High Blood Pressure: 11 people, 14.29%
Stress And Anxiety: 10 people, 12.99%
Insomnia (sleeplessness): 9 people, 11.69%
Depression: 9 people, 11.69%
Inflammation: 8 people, 10.39%

* Approximation only. Some reports may have incomplete information.

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