Cerebyx and Rocephin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cerebyx (fosphenytoin sodium) and Rocephin (ceftriaxone sodium). Common drug interactions include blood creatine phosphokinase increased among females and stevens-johnson syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Cerebyx and Rocephin. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Cerebyx?

Cerebyx has active ingredients of fosphenytoin sodium. eHealthMe is studying from 515 Cerebyx users. Check the latest studies of Cerebyx.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

On Jul, 27, 2026

12 people who take Cerebyx and Rocephin together, and have interactions are studied.

What are the common drug interactions of Cerebyx and Rocephin, by gender? *:

female:

Blood creatine phosphokinase increased
Cardiac arrest
Hyperkalaemia (damage to or disease of the kidney)
Hypokalaemia (low potassium)
Hypotension (abnormally low blood pressure)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Ventricular arrhythmia (problem with the rate or rhythm of the heartbeat)
Ventricular dysfunction (heart dysfunction)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)

male:

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Arteriosclerosis obliterans (thickening and hardening of arteries)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Hypokalaemia (low potassium)
Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Pyrexia (fever)
Respiratory distress (difficulty in breathing)

What are the common drug interactions of Cerebyx and Rocephin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Blood creatine phosphokinase increased
Cardiac arrest
Hyperkalaemia (damage to or disease of the kidney)
Hypokalaemia (low potassium)
Hypotension (abnormally low blood pressure)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Ventricular arrhythmia (problem with the rate or rhythm of the heartbeat)
Ventricular dysfunction (heart dysfunction)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

20-29:

n/a

30-39:

Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Hypokalaemia (low potassium)

40-49:

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

50-59:

n/a

60+:

Arteriosclerosis obliterans (thickening and hardening of arteries)
Coronary artery stenosis (narrowing of coronary artery)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug administration error
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Pyrexia (fever)

What are the existing conditions these people have? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 41.67%
Pulmonary Embolism (blockage of the main artery of the lung): 3 people, 25.00%
Itching: 3 people, 25.00%
Agitation (state of anxiety or nervous excitement): 3 people, 25.00%
Sedation: 2 people, 16.67%
Pneumonia: 1 person, 8.33%
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges): 1 person, 8.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 8.33%
Fever: 1 person, 8.33%
Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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