Cerebyx and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cerebyx (fosphenytoin sodium) and Zide (hydrochlorothiazide). Common drug interactions include gastrooesophageal reflux disease among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Cerebyx and Zide. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Cerebyx?

Cerebyx has active ingredients of fosphenytoin sodium. eHealthMe is studying from 515 Cerebyx users. Check the latest studies of Cerebyx.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

On Jul, 12, 2026

15 people who take Cerebyx and Zide together, and have interactions are studied.

What are the common drug interactions of Cerebyx and Zide, by gender? *:

female:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Mouth haemorrhage (bleeding from mouth)
Nausea (feeling of having an urge to vomit)
Pain
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Renal failure acute (rapid kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting
Acute respiratory distress syndrome

male:

Anaemia (lack of blood)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Loss of consciousness
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Urinary tract infection
Anticonvulsant drug level below therapeutic
Haematuria (presence of blood in urine)
Urinary bladder haemorrhage (urinary bladder bleeding)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Cerebyx and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Intracranial venous sinus thrombosis (presence of thrombosis (a blood clot) in the dural venous sinuses, which drain blood from the brain)

50-59:

Periarthritis (inflammation of the external coats of an artery and of the tissues around the artery)
Petechiae (a small red or purple spot caused by bleeding into the skin)
Photopsia (presence of perceived flashes of light)
Pleural effusion (water on the lungs)
Pneumonia bacterial (pneumonia associated with bacterial infection)
Rales (an abnormal respiratory sound characterized by fine crackles)
Red blood cell schistocytes present
Renal failure acute (rapid kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Swelling

60+:

Renal failure (kidney dysfunction)
Anaemia (lack of blood)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Urinary tract infection
Anticonvulsant drug level below therapeutic
Fall
Haematuria (presence of blood in urine)
Urinary bladder haemorrhage (urinary bladder bleeding)
Anuria (failure of the kidneys to produce urine)
Benign prostatic hyperplasia (benign enlargement of the prostate)

What are the existing conditions these people have? *

Breast Cancer: 6 people, 40.00%
Breast Cancer Metastatic: 6 people, 40.00%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 33.33%
Urinary Tract Infection: 4 people, 26.67%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 4 people, 26.67%
Enlarged Prostate: 3 people, 20.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 20.00%
Pain: 2 people, 13.33%
Csf Volume Increased: 1 person, 6.67%
Diabetes: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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