Cevimeline and Metolazone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cevimeline (cevimeline hydrochloride) and Metolazone (metolazone). Common drug interactions include chronic kidney disease among females and malaise among males.

The phase IV clinical study analyzes what interactions people have when they take Cevimeline and Metolazone. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Cevimeline?

Cevimeline has active ingredients of cevimeline hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 1,480 Cevimeline users. Check the latest studies of Cevimeline.

What is Metolazone?

Metolazone has active ingredients of metolazone. It is often used in swelling. eHealthMe is studying from 13,411 Metolazone users. Check the latest studies of Metolazone.

On Jul, 25, 2026

22 people who take Cevimeline and Metolazone together, and have interactions are studied.

Cevimeline and Metolazone drug interactions.

What are the common drug interactions of Cevimeline and Metolazone, by gender? *:

female:

Chronic kidney disease
Pruritus (severe itching of the skin)
Drug hypersensitivity
Pneumonia
Nephrogenic anaemia (anaemia due to kidney disease)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Cardiac failure congestive
Dry skin
Dyspnoea (difficult or laboured respiration)

male:

Malaise (a feeling of general discomfort or uneasiness)
Abdominal distension
Blood alkaline phosphatase increased
Blood lactic acid increased
Chest discomfort
Confusional state
Coronary arterial stent insertion
Cough
Dyspnoea (difficult or laboured respiration)
Ejection fraction decreased (systolic heart failure)

What are the common drug interactions of Cevimeline and Metolazone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Cardiac failure congestive
Dyspnoea (difficult or laboured respiration)
Fluid overload (too much fluid in the blood)
Nephropathy (damage to or disease of a kidney)
Oxygen consumption increased
Peripheral swelling

50-59:

Chronic kidney disease

60+:

Malaise (a feeling of general discomfort or uneasiness)
Thrombosis (formation of a blood clot inside a blood vessel)
Blood albumin decreased
Blood alkaline phosphatase increased
Blood lactic acid increased
Chest discomfort
Confusional state
Coronary arterial stent insertion
Cough
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 9 people, 40.91%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 18.18%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 13.64%
Rashes (redness): 2 people, 9.09%
Pain: 2 people, 9.09%
Hypokalemia (low potassium): 2 people, 9.09%
High Blood Pressure: 2 people, 9.09%
High Blood Cholesterol: 2 people, 9.09%
Gastric Ulcer (stomach ulcer): 2 people, 9.09%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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