Chantix and Edurant drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chantix (varenicline tartrate) and Edurant (rilpivirine hydrochloride). Common drug interactions include anhedonia among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Chantix and Edurant. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Chantix?

Chantix has active ingredients of varenicline tartrate. It is often used in quit smoking. eHealthMe is studying from 89,889 Chantix users. Check the latest studies of Chantix.

What is Edurant?

Edurant has active ingredients of rilpivirine hydrochloride. eHealthMe is studying from 2,238 Edurant users. Check the latest studies of Edurant.

On Jul, 28, 2026

17 people who take Chantix and Edurant together, and have interactions are studied.

What are the common drug interactions of Chantix and Edurant, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Emotional distress
Pain
Decreased activity
Dysstasia (difficulty in standing)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Quality of life decreased

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Quality of life decreased
Bone loss
Multiple fractures
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Decreased activity
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Femur fracture
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)

What are the common drug interactions of Chantix and Edurant, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Emotional distress
Lethargy (tiredness)
Pain
Quality of life decreased
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Renal failure (kidney dysfunction)

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Bone loss
Chronic kidney disease
Depression
Emotional distress
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Femur fracture
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Decreased activity
Emotional distress
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain
Quality of life decreased
Spinal compression fracture (fracture due to spinal compression on bone)
Upper limb fracture

50-59:

Emotional distress
Pain
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Bone density decreased
Chronic kidney disease
Depression
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Renal disorder (kidney disease)
Renal failure (kidney dysfunction)

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Depression
Emotional distress
Mobility decreased (ability to move is reduced)
Pain
Osteopenia (a condition where bone mineral density is lower than normal)

What are the existing conditions these people have? *

Hiv Infection: 17 people, 100.00%
High Blood Pressure: 6 people, 35.29%
Depression: 5 people, 29.41%
Bacterial Infection: 5 people, 29.41%
Pain: 4 people, 23.53%
Hypersensitivity: 4 people, 23.53%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 23.53%
Fungal Infection: 4 people, 23.53%
Erection Problems: 4 people, 23.53%
Inflammation: 4 people, 23.53%

* Approximation only. Some reports may have incomplete information.

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