Chantix and Imodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chantix (varenicline tartrate) and Imodium (loperamide hydrochloride). Common drug interactions include depression among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Chantix and Imodium. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Chantix?

Chantix has active ingredients of varenicline tartrate. It is often used in quit smoking. eHealthMe is studying from 89,889 Chantix users. Check the latest studies of Chantix.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

On Jul, 16, 2026

58 people who take Chantix and Imodium together, and have interactions are studied.

What are the common drug interactions of Chantix and Imodium, by gender? *:

female:

Depression
Hypertension (high blood pressure)
Tremor (trembling or shaking movements in one or more parts of your body)
Drug hypersensitivity
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Blood glucose decreased
Blood glucose increased
Blood iron decreased
Decreased appetite
Dry skin

male:

Anxiety
Osteoporosis (bones weak and more likely to break)
Depression
Dizziness
Fall
Nephrolithiasis (calculi in the kidneys)
Pneumonia
Pruritus (severe itching of the skin)
Rash
Skin discolouration (change of skin colour)

What are the common drug interactions of Chantix and Imodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal discomfort
Anaemia (lack of blood)
Arthralgia (joint pain)
Dehydration (dryness resulting from the removal of water)
Drug hypersensitivity
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Hypotension (abnormally low blood pressure)
Infection

30-39:

Colitis microscopic (inflammation of colon with diarrhoea and abdominal cramps)
Hyperhidrosis (abnormally increased sweating)
Oral herpes (viral infection of mouth)
Abdominal pain upper
Biliary colic
Chest pain
Cholecystitis chronic (long lasting infection of gallbladder)
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)

40-49:

Swelling face
Nausea (feeling of having an urge to vomit)
Fungal infection
Lip swelling
Anal abscess
Cough
Oropharyngeal pain
Pyrexia (fever)
Weight decreased

50-59:

Hydrocephalus (water on the brain)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Intervertebral disc degeneration (spinal disc degeneration)
Iron deficiency
Ligament sprain (ligament stretched)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Multiple fractures

60+:

Nausea (feeling of having an urge to vomit)
Tremor (trembling or shaking movements in one or more parts of your body)
Frustration (a form of poorly expressed anger)
Hypertension (high blood pressure)
Somnolence (a state of near-sleep, a strong desire for sleep)
Stress
Vomiting
Hypersensitivity
Muscle spasms (muscle contraction)
Chronic kidney disease

What are the existing conditions these people have? *

High Blood Pressure: 12 people, 20.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 18.97%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 12.07%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 12.07%
Diabetes: 6 people, 10.34%
Neuralgia (pain in one or more nerves): 5 people, 8.62%
Nausea (feeling of having an urge to vomit): 5 people, 8.62%
Pain: 5 people, 8.62%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 6.90%
Depression: 4 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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