Chantix and Relafen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chantix (varenicline tartrate) and Relafen (nabumetone). Common drug interactions include tooth extraction among females and actinic keratosis among males.

The phase IV clinical study analyzes what interactions people have when they take Chantix and Relafen. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Chantix?

Chantix has active ingredients of varenicline tartrate. It is often used in quit smoking. eHealthMe is studying from 89,889 Chantix users. Check the latest studies of Chantix.

What is Relafen?

Relafen has active ingredients of nabumetone. It is often used in arthritis. eHealthMe is studying from 6,243 Relafen users. Check the latest studies of Relafen.

On Jul, 15, 2026

48 people who take Chantix and Relafen together, and have interactions are studied.

What are the common drug interactions of Chantix and Relafen, by gender? *:

female:

Tooth extraction
Weight decreased
White blood cell count decreased
Arthropathy
Bone pain
Intervertebral disc disorder (spinal disc disorder)
Intervertebral disc protrusion (spinal disc protrusion)
Lumbar radiculopathy (radicular pain in the low back and legs)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Nerve root lesion (a localized change in nerve root tissue)

male:

Actinic keratosis (skin disease due to sun exposure)
Adenoma benign (non-cancerous tumour -secreting)
Melanocytic naevus (a type of lesion that contains nevus cells (a type of melanocyte))
Neuropathy peripheral (surface nerve damage)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Polyp
Rectal haemorrhage (bleeding from anus)
Telangiectasia (small dilated blood vessels near the surface of the skin)
Cellulitis (infection under the skin)

What are the common drug interactions of Chantix and Relafen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Fatigue (feeling of tiredness)
Influenza like illness
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Vomiting

30-39:

n/a

40-49:

Anxiety
Depression
Nightmare (unpleasant dream)
Suicidal ideation
Suicide attempt
Abnormal behaviour
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Delusion (a false belief or opinion)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)

50-59:

Nausea (feeling of having an urge to vomit)
Hostility
Migraine (headache)
Vomiting
Anxiety
Depression
Fall
Oral disorder (mouth disease)
Abdominal pain
Abscess neck (neck abscesses)

60+:

Nausea (feeling of having an urge to vomit)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Abnormal dreams
Blood potassium increased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hypotension (abnormally low blood pressure)
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Vomiting

What are the existing conditions these people have? *

Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 10 people, 20.83%
Anaemia (lack of blood): 10 people, 20.83%
Multiple Myeloma (cancer of the plasma cells): 9 people, 18.75%
Pain: 8 people, 16.67%
Stress And Anxiety: 5 people, 10.42%
High Blood Pressure: 5 people, 10.42%
Depression: 5 people, 10.42%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 10.42%
Affective Disorder (mental disorder): 5 people, 10.42%
Sleep Disorder: 4 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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