Chlor-trimeton and Prograf drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chlor-trimeton (chlorpheniramine maleate) and Prograf (tacrolimus). Common drug interactions include postresuscitation encephalopathy among females and fungal infection among males.

The phase IV clinical study analyzes what interactions people have when they take Chlor-trimeton and Prograf. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Chlor-trimeton?

Chlor-trimeton has active ingredients of chlorpheniramine maleate. It is often used in allergies. eHealthMe is studying from 1,472 Chlor-trimeton users. Check the latest studies of Chlor-trimeton.

What is Prograf?

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.

On Jul, 08, 2026

31 people who take Chlor-trimeton and Prograf together, and have interactions are studied.

Chlor-trimeton and Prograf drug interactions.

What are the common drug interactions of Chlor-Trimeton and Prograf, by gender? *:

female:

Postresuscitation encephalopathy
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Acute graft versus host disease in intestine (acute complication in intestine following an allogeneic tissue/blood transplant)
Acute graft versus host disease in liver (acute complication in liver following an allogeneic tissue/blood transplant)
Acute lymphocytic leukaemia (cancer of the white blood cells)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Ascites (accumulation of fluid in the abdominal cavity)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Cardiac arrest

male:

Fungal infection
Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
Diarrhoea
Pyrexia (fever)
Acute graft versus host disease in liver (acute complication in liver following an allogeneic tissue/blood transplant)
Thyroiditis chronic (long lasting inflammation of thyroid gland)
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Acute graft versus host disease in intestine (acute complication in intestine following an allogeneic tissue/blood transplant)
Alanine aminotransferase increased
Aspartate aminotransferase increased

What are the common drug interactions of Chlor-Trimeton and Prograf, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Blood bilirubin increased
Blood potassium decreased
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)

10-19:

Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Respiratory disorder (respiratory disease)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Cytomegalovirus test positive
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Febrile neutropenia (fever with reduced white blood cells)
Pyrexia (fever)
Engraftment syndrome (inflammatory condition during neutrophil recovery after hematopoietic stem cell transplantation)
Alanine aminotransferase increased

20-29:

Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Glossoptosis
Postresuscitation encephalopathy
Renal impairment (severely reduced kidney function)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Acute lymphocytic leukaemia (cancer of the white blood cells)
Bone marrow failure
Constipation
Dysuria (painful or difficult urination)
Gastritis (inflammation of stomach)

30-39:

Asthma
Pyrexia (fever)
Bacterial infection
Chest pain
Cough
Cystitis haemorrhagic (blood in the urine and painful voiding)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Diarrhoea
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Graft versus host disease in lung (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the lung)

40-49:

n/a

50-59:

Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood bilirubin increased
Cytomegalovirus enterocolitis (virus infection of intestine and colon)
Drug ineffective
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Metastases to abdominal cavity (cancer spreads to abdominal cavity)
Metastases to lymph nodes (cancer spreads to lymph node)

60+:

Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
Cytomegalovirus infection
Acute graft versus host disease in intestine (acute complication in intestine following an allogeneic tissue/blood transplant)
Acute graft versus host disease in liver (acute complication in liver following an allogeneic tissue/blood transplant)
Diarrhoea
Thyroiditis chronic (long lasting inflammation of thyroid gland)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Cytomegalovirus test positive
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Renal impairment (severely reduced kidney function)

What are the existing conditions these people have? *

Bone Marrow Conditioning Regimen: 13 people, 41.94%
High Blood Pressure: 8 people, 25.81%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 8 people, 25.81%
Renal Impairment (severely reduced kidney function): 7 people, 22.58%
Insomnia (sleeplessness): 7 people, 22.58%
Fever: 6 people, 19.35%
Oral Disorder (mouth disease): 5 people, 16.13%
Hepatic Function Abnormal: 5 people, 16.13%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 5 people, 16.13%
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low): 5 people, 16.13%

* Approximation only. Some reports may have incomplete information.

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