Chlorhexidine gluconate and Fluoride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chlorhexidine gluconate (chlorhexidine gluconate) and Fluoride (fluoride). Common drug interactions include glossodynia among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Chlorhexidine gluconate and Fluoride. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Chlorhexidine gluconate?

Chlorhexidine gluconate has active ingredients of chlorhexidine gluconate. eHealthMe is studying from 8,233 Chlorhexidine gluconate users. Check the latest studies of Chlorhexidine gluconate.

What is Fluoride?

Fluoride has active ingredients of fluoride. eHealthMe is studying from 2,301 Fluoride users. Check the latest studies of Fluoride.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

39 people who take Chlorhexidine gluconate and Fluoride together, and have interactions are studied.

Chlorhexidine gluconate and Fluoride drug interactions.

What are the common drug interactions of Chlorhexidine Gluconate and Fluoride, by gender? *:

female:

Glossodynia (a burning or painful sensation in the tongue)
Hand deformity
Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
Hepatic enzyme increased
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hypertension (high blood pressure)
Impaired healing
Infusion related reaction
Irritable bowel syndrome
Joint range of motion decreased (disease of joint movement)

male:

Death
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Chest pain
Encephalitis (inflammation of the brain)
Febrile neutropenia (fever with reduced white blood cells)
Gastric cancer recurrent (repeat stomach cancer)

What are the common drug interactions of Chlorhexidine Gluconate and Fluoride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Alanine aminotransferase increased
Anaemia (lack of blood)
Aspartate aminotransferase increased
Blood bilirubin increased
Cough
Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Gamma-glutamyltransferase increased
Hyperglycaemia (high blood sugar)
Hyperkalaemia (damage to or disease of the kidney)

10-19:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Acute respiratory distress syndrome
Bone density decreased
Breath odour
Dyskinesia (abnormality or impairment of voluntary movement)
Encephalitis (inflammation of the brain)
Haemorrhage (bleeding)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Mastoiditis (infection of mastoid bone)
Mouth ulceration (mouth ulcers)

20-29:

n/a

30-39:

n/a

40-49:

Road traffic accident
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Seronegative arthritis (a joint disease negative for rheumatoid arthritis)
Sinusitis (inflammation of sinus)
Sleep disorder
Sleep disorder due to general medical condition, insomnia type (a conditions that prevent a person from getting restful sleep due to mental condition of not getting sleep)
Spinal fusion surgery
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Ulcer haemorrhage (bleeding ulcer)
Upper respiratory tract infection

50-59:

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Chest pain
Pneumonia
Abasia (inability to walk)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Comminuted fracture (bone has broken into several pieces)
Culture urine positive
Diarrhoea

60+:

Death
Renal failure (kidney dysfunction)
Fall
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hepatic failure (liver failure)
Hip fracture
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Post procedural haemorrhage (post procedural bleeding)
Skin haemorrhage (bleeding into skin)
Chronic kidney disease

What are the existing conditions these people have? *

Hypersensitivity: 5 people, 12.82%
Pain: 5 people, 12.82%
High Blood Cholesterol: 5 people, 12.82%
High Blood Pressure: 5 people, 12.82%
Wound: 4 people, 10.26%
Asthma: 4 people, 10.26%
Dyspnea (difficult or laboured breathing): 4 people, 10.26%
Fungal Infection: 4 people, 10.26%
Headache (pain in head): 4 people, 10.26%
Herpes Zoster: 4 people, 10.26%

* Approximation only. Some reports may have incomplete information.

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