Chlorhexidine gluconate and Rocephin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chlorhexidine gluconate (chlorhexidine gluconate) and Rocephin (ceftriaxone sodium). Common drug interactions include toothache among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Chlorhexidine gluconate and Rocephin. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Chlorhexidine gluconate?

Chlorhexidine gluconate has active ingredients of chlorhexidine gluconate. eHealthMe is studying from 8,233 Chlorhexidine gluconate users. Check the latest studies of Chlorhexidine gluconate.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

70 people who take Chlorhexidine gluconate and Rocephin together, and have interactions are studied.

Chlorhexidine gluconate and Rocephin drug interactions.

What are the common drug interactions of Chlorhexidine Gluconate and Rocephin, by gender? *:

female:

Toothache (tooth pain)
Abdominal pain
Atelectasis (partial or complete collapse of the lung)
Oedema peripheral (superficial swelling)
Nausea (feeling of having an urge to vomit)
Vomiting
Anaemia (lack of blood)
Fatigue (feeling of tiredness)
Dental caries
Back pain

male:

Diarrhoea
Hypertension (high blood pressure)
Cellulitis (infection under the skin)
Dyspnoea (difficult or laboured respiration)
Leukopenia (less number of white blood cells in blood)
Neutropenia (an abnormally low number of neutrophils)
Osteonecrosis of jaw (death of bone of jaw)
Abdominal pain
Arthralgia (joint pain)
Balance disorder

What are the common drug interactions of Chlorhexidine Gluconate and Rocephin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pyrexia (fever)
Abdominal pain upper
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood glucose increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Cardiomegaly (increased size of heart than normal)
Cardiomyopathy (weakening of the heart muscle)

30-39:

Actinomycosis (infection that causes sores, or abscesses)
Acute respiratory failure
Adenoma benign (non-cancerous tumour -secreting)
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Apical granuloma (tumour of the apex of a nonvital tooth)
Atelectasis (partial or complete collapse of the lung)
Atrophic vulvovaginitis (inflammation of the vulva)

40-49:

Osteonecrosis of jaw (death of bone of jaw)
Anxiety
Depression
Osteomyelitis (infection of bone)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Myalgia (muscle pain)
Arthralgia (joint pain)
Osteopenia (a condition where bone mineral density is lower than normal)
Pain
Pain in jaw

50-59:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Hypoxia (low oxygen in tissues)
Oedema peripheral (superficial swelling)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteomyelitis (infection of bone)
Pain in jaw
Pleural effusion (water on the lungs)

60+:

Anaemia (lack of blood)
Anxiety
Hypertension (high blood pressure)
Injury
Leukopenia (less number of white blood cells in blood)
Lymphadenopathy (disease or enlargement of lymph nodes)
Osteopenia (a condition where bone mineral density is lower than normal)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Thrombocytopenia (decrease of platelets in blood)
Gingival pain (gum pain)

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 27 people, 38.57%
Stress And Anxiety: 23 people, 32.86%
Pain: 12 people, 17.14%
Chronic Thyroiditis (long lasting inflammation of thyroid gland): 8 people, 11.43%
Breast Cancer: 8 people, 11.43%

* Approximation only. Some reports may have incomplete information.

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