Chlorhexidine gluconate and Vivelle drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chlorhexidine gluconate (chlorhexidine gluconate) and Vivelle (estradiol). Common drug interactions include partner stress among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Chlorhexidine gluconate and Vivelle. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Chlorhexidine gluconate?

Chlorhexidine gluconate has active ingredients of chlorhexidine gluconate. eHealthMe is studying from 8,233 Chlorhexidine gluconate users. Check the latest studies of Chlorhexidine gluconate.

What is Vivelle?

Vivelle has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,624 Vivelle users. Check the latest studies of Vivelle.



On Aug, 05, 2026

13 people who take Chlorhexidine gluconate and Vivelle together, and have interactions are studied.

Chlorhexidine gluconate and Vivelle drug interactions.

What are the common drug interactions of Chlorhexidine Gluconate and Vivelle, by gender? *:

female:

  1. Partner stress
  2. Pyrexia (fever)
  3. Right atrial dilatation (enlargement of the right atrium chamber of heart)
  4. Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
  5. Streptococcal sepsis (whole body inflammation by streptococcal)
  6. Breast disorder
  7. Breast hyperplasia (accumulation of abnormal cells in a breast duct)
  8. Fibroadenoma of breast (breast lump)
  9. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  10. Headache (pain in head)

male:

  1. Anaemia (lack of blood)
  2. Anxiety
  3. Gingival disorder (gum disease)
  4. Hallucination, visual (seeing things that aren't there)
  5. Impaired healing
  6. Jaw disorder (jaw disease)
  7. Metastases to bone (cancer spreads to bone)
  8. Myalgia (muscle pain)
  9. Oral pain
  10. Osteoarthritis (a joint disease caused by cartilage loss in a joint)

What are the common drug interactions of Chlorhexidine Gluconate and Vivelle, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Herpes zoster
  2. Intervertebral disc degeneration (spinal disc degeneration)
  3. Keratomileusis
  4. Neck pain
  5. Oesophageal stenosis (narrowing of oesophagus)
  6. Oestrogen receptor assay positive
  7. Oral herpes (viral infection of mouth)
  8. Pelvic fracture
  9. Radiculitis lumbosacral (inflammation of nerve root at labosacral vertebrea)
  10. Rectocele (a bulging of the front wall of the rectum into the back wall of the vagina)

50-59:

  1. Depression
  2. Emotional distress
  3. General physical health deterioration (weak health status)
  4. Gingival disorder (gum disease)
  5. Hallucination, visual (seeing things that aren't there)
  6. Impaired healing
  7. Jaw disorder (jaw disease)
  8. Metastases to bone (cancer spreads to bone)
  9. Myalgia (muscle pain)
  10. Oral pain

60+:

  1. Fatigue (feeling of tiredness)
  2. Sjogren's syndrome (a disease that causes dryness in the mouth and eyes)

What are the existing conditions these people have? *

  1. Prostate Cancer: 7 people, 53.85%
  2. Metastases To Bone (cancer spreads to bone): 7 people, 53.85%
  3. Nausea (feeling of having an urge to vomit): 4 people, 30.77%
  4. Menopause (end of monthly cycles in women): 4 people, 30.77%
  5. Menopausal Symptoms: 2 people, 15.38%
  6. Skin Reaction: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Chlorhexidine gluconate and Vivelle?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Chlorhexidine gluconate and Vivelle:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Chlorhexidine gluconate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Vivelle:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Chlorhexidine gluconate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vivelle and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on chlorhexidine gluconate and estradiol (the active ingredients of Chlorhexidine gluconate and Vivelle, respectively), and Chlorhexidine gluconate and Vivelle (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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