Chlorthalidone and Morphine sulfate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chlorthalidone (chlorthalidone) and Morphine sulfate (morphine sulfate). Common drug interactions include chronic kidney disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Chlorthalidone and Morphine sulfate. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Chlorthalidone?

Chlorthalidone has active ingredients of chlorthalidone. It is often used in high blood pressure. eHealthMe is studying from 12,483 Chlorthalidone users. Check the latest studies of Chlorthalidone.

What is Morphine sulfate?

Morphine sulfate has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 87,262 Morphine sulfate users. Check the latest studies of Morphine sulfate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

96 people who take Chlorthalidone and Morphine sulfate together, and have interactions are studied.

Chlorthalidone and Morphine sulfate drug interactions.

What are the common drug interactions of Chlorthalidone and Morphine Sulfate, by gender? *:

female:

Chronic kidney disease
Depression
Fatigue (feeling of tiredness)
Pain in extremity
Balance disorder
Cardiac arrest
Drug hypersensitivity
Encephalopathy (functioning of the brain is affected by some agent or condition)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)

male:

Chronic kidney disease
Syncope (loss of consciousness with an inability to maintain postural tone)
Contusion (a type of hematoma of tissue in which capillaries)
Exostosis (formation of new bone on the surface of a bone)
Hyperhidrosis (abnormally increased sweating)
Injury
Intervertebral disc space narrowing (spinal disc space narrowing)
Loss of consciousness
Neck pain
Nephrolithiasis (calculi in the kidneys)

What are the common drug interactions of Chlorthalidone and Morphine Sulfate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hypoaesthesia (reduced sense of touch or sensation)
Nerve compression
Neuralgia (pain in one or more nerves)
Peripheral swelling
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight decreased
Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
Nerve injury
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Drug ineffective

50-59:

Loss of consciousness
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Nephrolithiasis (calculi in the kidneys)
Nightmare (unpleasant dream)
Sedation
Sepsis (a severe blood infection that can lead to organ failure and death)
Headache (pain in head)
Abscess (pus)
Actinomycosis (infection that causes sores, or abscesses)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

60+:

Syncope (loss of consciousness with an inability to maintain postural tone)
Fatigue (feeling of tiredness)
Chronic kidney disease
Death
Encephalopathy (functioning of the brain is affected by some agent or condition)
Erythema (redness of the skin)
Oedema peripheral (superficial swelling)
Sepsis (a severe blood infection that can lead to organ failure and death)
Throat tightness
Tremor (trembling or shaking movements in one or more parts of your body)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 15.62%
Fibromyalgia (a long-term condition which causes pain all over the body): 12 people, 12.50%
High Blood Cholesterol: 11 people, 11.46%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 10.42%
Neuralgia (pain in one or more nerves): 9 people, 9.38%
Insomnia (sleeplessness): 9 people, 9.38%
Hypersensitivity: 8 people, 8.33%
Fluid Retention (an abnormal accumulation of fluid in the blood): 7 people, 7.29%
Fungal Infection: 7 people, 7.29%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 7.29%

* Approximation only. Some reports may have incomplete information.

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