Cimetidine and Duloxetine hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cimetidine (cimetidine) and Duloxetine hydrochloride (duloxetine hydrochloride). Common drug interactions include abdominal discomfort among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Cimetidine and Duloxetine hydrochloride. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Cimetidine?

Cimetidine has active ingredients of cimetidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 10,531 Cimetidine users. Check the latest studies of Cimetidine.

What is Duloxetine hydrochloride?

Duloxetine hydrochloride has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 17,410 Duloxetine hydrochloride users. Check the latest studies of Duloxetine hydrochloride.

On Jul, 09, 2026

23 people who take Cimetidine and Duloxetine hydrochloride together, and have interactions are studied.

Cimetidine and Duloxetine hydrochloride drug interactions.

What are the common drug interactions of Cimetidine and Duloxetine Hydrochloride, by gender? *:

female:

Abdominal discomfort
Dyspnoea (difficult or laboured respiration)
Urticaria (rash of round, red welts on the skin that itch intensely)
Back pain
Catheter site swelling
Chest discomfort
Chest pain
Dyspnoea exertional (breathlessness or shortness of breath)
Ear haemorrhage (bleeding from ear)
Eye swelling

male:

Death
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the common drug interactions of Cimetidine and Duloxetine Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood glucose increased
Blood potassium increased
Drug diversion
Dyspnoea (difficult or laboured respiration)
Foaming at mouth (excess saliva secretion)
Hepatic enzyme increased
Oxygen saturation decreased
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Unresponsive to stimuli
White blood cell count increased

40-49:

Abdominal discomfort
Decreased appetite
Dry mouth
Nausea (feeling of having an urge to vomit)
Polydipsia (excessive thirst)

50-59:

Blood pressure increased
Catheter site swelling
Chest discomfort
Chest pain
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Ear haemorrhage (bleeding from ear)
Eye swelling
Fatigue (feeling of tiredness)

60+:

Death
Decreased appetite
Pneumonia
Pruritus (severe itching of the skin)
Respiratory failure (inadequate gas exchange by the respiratory system)
Skin ulcer
Therapeutic response decreased (less preventive response)
Weight decreased

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 6 people, 26.09%
Pain: 4 people, 17.39%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 17.39%
Migraine (headache): 4 people, 17.39%
Sleep Disorder: 3 people, 13.04%
Insomnia (sleeplessness): 3 people, 13.04%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 13.04%
Neuropathy Peripheral (surface nerve damage): 2 people, 8.70%
Neurodermatitis (a skin disorder characterized by long lasting itching and scratching): 2 people, 8.70%
Nausea (feeling of having an urge to vomit): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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