Cimetidine and Senna drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cimetidine (cimetidine) and Senna (senna). Common drug interactions include panic reaction among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Cimetidine and Senna. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Cimetidine?

Cimetidine has active ingredients of cimetidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 10,531 Cimetidine users. Check the latest studies of Cimetidine.

What is Senna?

Senna has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 37,302 Senna users. Check the latest studies of Senna.

On Jul, 29, 2026

47 people who take Cimetidine and Senna together, and have interactions are studied.

What are the common drug interactions of Cimetidine and Senna, by gender? *:

female:

Panic reaction
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Psychogenic pain disorder
Social avoidant behaviour (avoiding social connection a personality disorder)
Substance-induced psychotic disorder
Adverse drug reaction
Pruritus (severe itching of the skin)
Anxiety disorder
Chronic kidney disease
Contusion (a type of hematoma of tissue in which capillaries)

male:

Anxiety
Cough
Ear infection
Fall
Upper respiratory tract infection
Viral pharyngitis (inflammation of the throat or pharynx caused by viral infection)
Bipolar disorder (mood disorder)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Eczema eyelids (patches of skin become rough and inflamed, with itching and bleeding blisters on eyelid)

What are the common drug interactions of Cimetidine and Senna, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Anxiety
Attention deficit/hyperactivity disorder
B-cell lymphoma (blood cancer affecting b cells)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Conjunctivitis (pink eye)
Cough
Depression
Ear infection
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Eczema eyelids (patches of skin become rough and inflamed, with itching and bleeding blisters on eyelid)

10-19:

n/a

20-29:

n/a

30-39:

Alanine aminotransferase increased
Back pain
Blood creatinine decreased
Eye pain
Fatigue (feeling of tiredness)
Gait disturbance
Headache (pain in head)
Pain
Pain in extremity
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)

40-49:

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Muscle atrophy (a decrease in the mass of the muscle)
Myalgia (muscle pain)
Myelopathy (any neurologic deficit related to the spinal cord)
Nausea (feeling of having an urge to vomit)
Neurogenic bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion)
Neuropathy peripheral (surface nerve damage)
Nocturia (the need to get up in the night to urinate)
Oesophageal stenosis (narrowing of oesophagus)
Oral candidiasis (fungal infection of mouth)

50-59:

Anxiety disorder
Arthralgia (joint pain)
Asthenia (weakness)
Atrophy (wasting away of a part of the body)
Back pain
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Contusion (a type of hematoma of tissue in which capillaries)
Depression
Fall
Insomnia (sleeplessness)

60+:

Cerebral haemorrhage (bleeding within the brain)
Epistaxis (bleed from the nose)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Head injury
Rib fracture
Subdural haematoma (blood collects between the skull and the surface of the brain)
Anisocytosis (patient's red blood cells are of unequal size)

What are the existing conditions these people have? *

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 8 people, 17.02%
Multiple Myeloma (cancer of the plasma cells): 6 people, 12.77%
Metastases To Bone (cancer spreads to bone): 5 people, 10.64%
High Blood Pressure: 5 people, 10.64%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 5 people, 10.64%
Pain: 4 people, 8.51%
Diabetes: 4 people, 8.51%
Sleep Disorder: 3 people, 6.38%
Ovarian Cancer (cancer of ovary): 3 people, 6.38%
Nausea (feeling of having an urge to vomit): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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